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Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.

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Title: Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.
Authors: Le NTT; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Mercer RCC; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Fang C; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Sundaravadivelu A; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Labadorf AT; Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America., Lin W; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Kwan J; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Blum B; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Emili A; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America., Harris DA; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2026 Jun 18; Vol. 22 (6), pp. e1014314. Date of Electronic Publication: 2026 Jun 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.
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  Data: <searchLink fieldCode="AU" term="%22Le+NTT%22">Le NTT</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Mercer+RCC%22">Mercer RCC</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Fang+C%22">Fang C</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Sundaravadivelu+A%22">Sundaravadivelu A</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Labadorf+AT%22">Labadorf AT</searchLink>; Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Lin+W%22">Lin W</searchLink>; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Kwan+J%22">Kwan J</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Blum+B%22">Blum B</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Emili+A%22">Emili A</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Harris+DA%22">Harris DA</searchLink>; Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America.
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              Text: 2026 Jun 18
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