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Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction.

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Title: Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction.
Authors: Ikushima YM; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Department of Medical Science and Innovation, SiRIUS Institute of Medical Research, Tohoku University, Sendai, Japan., Chen KC; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan., Sulston RJ; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Mattiucci D; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Brain EJ; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Fung Xin Zi SA; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Suchacki KJ; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Scotland's Rural College, The Roslin Institute, Easter Bush Campus, Edinburgh, United Kingdom., Thomas BJ; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Lovdel A; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Bennett M; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Kobayashi H; Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan.; Kanagawa Institute of Industrial Science and Technology (KISTEC), Kawasaki, Japan., Whitfield PD; Division of Biomedical Sciences, University of the Highlands and Islands, Centre for Health Sciences, Inverness, United Kingdom.; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom., Takubo K; Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan.; Kanagawa Institute of Industrial Science and Technology (KISTEC), Kawasaki, Japan., Baker AH; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Morton NM; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom., Semple RK; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom., Cawthorn WP; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.
Source: PLoS biology [PLoS Biol] 2026 Jun 18; Vol. 24 (6), pp. e3003821. Date of Electronic Publication: 2026 Jun 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction.
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  Data: <searchLink fieldCode="AU" term="%22Ikushima+YM%22">Ikushima YM</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Department of Medical Science and Innovation, SiRIUS Institute of Medical Research, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Chen+KC%22">Chen KC</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sulston+RJ%22">Sulston RJ</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mattiucci+D%22">Mattiucci D</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brain+EJ%22">Brain EJ</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fung+Xin+Zi+SA%22">Fung Xin Zi SA</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Suchacki+KJ%22">Suchacki KJ</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Scotland's Rural College, The Roslin Institute, Easter Bush Campus, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Thomas+BJ%22">Thomas BJ</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lovdel+A%22">Lovdel A</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bennett+M%22">Bennett M</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kobayashi+H%22">Kobayashi H</searchLink>; Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan.; Kanagawa Institute of Industrial Science and Technology (KISTEC), Kawasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Whitfield+PD%22">Whitfield PD</searchLink>; Division of Biomedical Sciences, University of the Highlands and Islands, Centre for Health Sciences, Inverness, United Kingdom.; Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Takubo+K%22">Takubo K</searchLink>; Department of Cell Fate Biology and Stem Cell Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Stem Cell Biology, National Institute of Global Health and Medicine, Japan Institute for Health Security (JIHS), Tokyo, Japan.; Kanagawa Institute of Industrial Science and Technology (KISTEC), Kawasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Baker+AH%22">Baker AH</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Morton+NM%22">Morton NM</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.; Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Semple+RK%22">Semple RK</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cawthorn+WP%22">Cawthorn WP</searchLink>; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh, United Kingdom.
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