Cu(I)-Catalyzed (4+1) Tandem Annulation of Terminal Alkynes with 2-(Tosylmethyl)phenols: Access to 2,3-Disubstituted Benzofurans and Mechanism Insights.

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Title: Cu(I)-Catalyzed (4+1) Tandem Annulation of Terminal Alkynes with 2-(Tosylmethyl)phenols: Access to 2,3-Disubstituted Benzofurans and Mechanism Insights.
Authors: Yan X; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.; State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China., Zhang W; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Li L; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Jiang J; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Cui Y; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Luo Y; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Liu Y; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Wang P; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Yuan K; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China., Shao PL; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China., Fan CA; State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Source: The Journal of organic chemistry [J Org Chem] 2026 Jul 03; Vol. 91 (26), pp. 9224-9230. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Cu(I)-Catalyzed (4+1) Tandem Annulation of Terminal Alkynes with 2-(Tosylmethyl)phenols: Access to 2,3-Disubstituted Benzofurans and Mechanism Insights.
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  Data: <searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.; State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Jiang+J%22">Jiang J</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Wang+P%22">Wang P</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Yuan+K%22">Yuan K</searchLink>; College of Chemical Engineering and Technology, Key Laboratory of Advanced Optoelectronic Functional Materials of Gansu Province, Key Laboratory for New Molecule Materials Design and Function of Gansu Universities, Tianshui Normal University, Tianshui 741001, China.<br /><searchLink fieldCode="AU" term="%22Shao+PL%22">Shao PL</searchLink>; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China.<br /><searchLink fieldCode="AU" term="%22Fan+CA%22">Fan CA</searchLink>; State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
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  Data: <searchLink fieldCode="JN" term="%222985193R%22">The Journal of organic chemistry</searchLink> [J Org Chem] 2026 Jul 03; Vol. 91 (26), pp. 9224-9230. <i>Date of Electronic Publication: </i>2026 Jun 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985193R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-6904 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223263%22">00223263 </searchLink><i>NLM ISO Abbreviation: </i>J Org Chem <i>Subsets: </i>MEDLINE; PubMed not MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1021/acs.joc.6c00215
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        Text: English
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        StartPage: 9224
    Titles:
      – TitleFull: Cu(I)-Catalyzed (4+1) Tandem Annulation of Terminal Alkynes with 2-(Tosylmethyl)phenols: Access to 2,3-Disubstituted Benzofurans and Mechanism Insights.
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            – D: 03
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              Text: 2026 Jul 03
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