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Deep learning of CT imaging predicts PD-L1 expression and immunotherapy response in metastatic NSCLC: A multi-center study.

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Title: Deep learning of CT imaging predicts PD-L1 expression and immunotherapy response in metastatic NSCLC: A multi-center study.
Authors: Muneer A; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Showkatian E; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Saad MB; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Hong L; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Li S; Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA., Salehjahromi M; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Aminu M; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Sujit SJ; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Xu H; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Waqas M; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Zafar A; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA., Shroff GS; Department of Thoracic Imaging, MD Anderson Cancer Center, Houston, TX, USA., Wu CC; Department of Thoracic Imaging, MD Anderson Cancer Center, Houston, TX, USA., Carter BW; Department of Thoracic Imaging, MD Anderson Cancer Center, Houston, TX, USA., Chang JY; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA., Liao Z; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA., Altan M; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Vokes NI; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Cascone T; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Le X; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Haymaker CL; Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX, USA., Wistuba II; Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX, USA., Chung C; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA; Institute for Data Science in Oncology, MD Anderson Cancer Center, Houston, TX, USA., Jaffray D; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; Institute for Data Science in Oncology, MD Anderson Cancer Center, Houston, TX, USA., Gibbons DL; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Vaporciyan A; Department of Thoracic and Cardiovascular Surgery, MD Anderson Cancer Center, Houston, TX, USA., Lee JJ; Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA., Lou Y; Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA., Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Zhang J; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, MD Anderson Cancer Center, Houston, TX, USA., Wu J; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA; Institute for Data Science in Oncology, MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jwu11@mdanderson.org.
Source: Cancer letters [Cancer Lett] 2026 Sep 28; Vol. 656, pp. 218687. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
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  Data: Deep learning of CT imaging predicts PD-L1 expression and immunotherapy response in metastatic NSCLC: A multi-center study.
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  Data: <searchLink fieldCode="AU" term="%22Muneer+A%22">Muneer A</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Showkatian+E%22">Showkatian E</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Saad+MB%22">Saad MB</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hong+L%22">Hong L</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Salehjahromi+M%22">Salehjahromi M</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Aminu+M%22">Aminu M</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Sujit+SJ%22">Sujit SJ</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Waqas+M%22">Waqas M</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zafar+A%22">Zafar A</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Shroff+GS%22">Shroff GS</searchLink>; Department of Thoracic Imaging, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wu+CC%22">Wu CC</searchLink>; Department of Thoracic Imaging, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Carter+BW%22">Carter BW</searchLink>; Department of Thoracic Imaging, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chang+JY%22">Chang JY</searchLink>; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Liao+Z%22">Liao Z</searchLink>; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Altan+M%22">Altan M</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vokes+NI%22">Vokes NI</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Cascone+T%22">Cascone T</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Le+X%22">Le X</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Haymaker+CL%22">Haymaker CL</searchLink>; Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wistuba+II%22">Wistuba II</searchLink>; Department of Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chung+C%22">Chung C</searchLink>; Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA; Institute for Data Science in Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jaffray+D%22">Jaffray D</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; Institute for Data Science in Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gibbons+DL%22">Gibbons DL</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Vaporciyan+A%22">Vaporciyan A</searchLink>; Department of Thoracic and Cardiovascular Surgery, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lou+Y%22">Lou Y</searchLink>; Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Heymach+JV%22">Heymach JV</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX, USA; Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA; Institute for Data Science in Oncology, MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jwu11@mdanderson.org.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2026 Sep 28; Vol. 656, pp. 218687. <i>Date of Electronic Publication: </i>2026 Jun 19.
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  Data: Journal Article; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland%22">Elsevier Science Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600053 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043835%22">03043835 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Lett <i>Subsets: </i>MEDLINE
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