Intraocular delivery of crystalline sorafenib provides sustained, potent inhibition of wet age-related macular degeneration.

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Title: Intraocular delivery of crystalline sorafenib provides sustained, potent inhibition of wet age-related macular degeneration.
Authors: Lu H; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Rakoski AI; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Ri K; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Zhou L; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Shi L; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cho H; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wu S; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chen SS; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Neill AN; Department of Chemistry, The Johns Hopkins University, Baltimore, MD, USA., Catazaro J; Department of Chemistry, The Johns Hopkins University, Baltimore, MD, USA., Wong VW; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Yoo A; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Wilson DS; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA., Doloff JC; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Materials Science and Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA; Department of Oncology, Division of Cancer Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jcdoloff@jhu.edu., Duh EJ; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: eduh@jhmi.edu.
Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 Jun 18; Vol. 397, pp. 115120. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
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  Data: Intraocular delivery of crystalline sorafenib provides sustained, potent inhibition of wet age-related macular degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rakoski+AI%22">Rakoski AI</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ri+K%22">Ri K</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shi+L%22">Shi L</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cho+H%22">Cho H</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chen+SS%22">Chen SS</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Neill+AN%22">Neill AN</searchLink>; Department of Chemistry, The Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Catazaro+J%22">Catazaro J</searchLink>; Department of Chemistry, The Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wong+VW%22">Wong VW</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Yoo+A%22">Yoo A</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+DS%22">Wilson DS</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Doloff+JC%22">Doloff JC</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Materials Science and Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA; Department of Oncology, Division of Cancer Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jcdoloff@jhu.edu.<br /><searchLink fieldCode="AU" term="%22Duh+EJ%22">Duh EJ</searchLink>; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: eduh@jhmi.edu.
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