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Early oligodendrocyte dysfunction signature in Alzheimer's disease: Insights from DNA methylomics and transcriptomics.

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Title: Early oligodendrocyte dysfunction signature in Alzheimer's disease: Insights from DNA methylomics and transcriptomics.
Authors: Fodder K; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Smith HMG; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Yaman U; UK Dementia Research Institute, London, UK., Piras IS; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA., Murthy M; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK., Hardy J; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK., Lashley T; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., de Silva R; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK., Salih DA; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK., Bettencourt C; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. c.bettencourt@ucl.ac.uk.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fodder+K%22">Fodder K</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Smith+HMG%22">Smith HMG</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Yaman+U%22">Yaman U</searchLink>; UK Dementia Research Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Piras+IS%22">Piras IS</searchLink>; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Murthy+M%22">Murthy M</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Hardy+J%22">Hardy J</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Lashley+T%22">Lashley T</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22de+Silva+R%22">de Silva R</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Salih+DA%22">Salih DA</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; UK Dementia Research Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Bettencourt+C%22">Bettencourt C</searchLink>; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK. c.bettencourt@ucl.ac.uk.
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        Value: 10.1038/s41380-026-03686-1
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        Text: English
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              Text: 2026 Jun 18
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