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HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB-DPP4 signaling.

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Title: HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB-DPP4 signaling.
Authors: Ng SC; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan, ROC., Kao SW; Department of Orthopedic Surgery, Chung-Shan Medical University Hospital, Taichung, Taiwan, ROC.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC., Chen CJ; Division of Breast Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan, ROC., Lin SZ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ROC.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ROC., Hsieh DJ; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, ROC., Kuo CH; Laboratory of Exercise Biochemistry, Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong SAR, China.; Faculty of Sport Science, The University of Jordan, Amman, Jordan.; School of Physical Education, Suzhou, Jiangsu, China., Lin KH; College of Medicine, China Medical University, Taichung, Taiwan ROC.; Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan ROC., Huang CY; Center for Molecular Medicine in Traditional Chinese Medicine, E-Da Hospital, E-Da Healthcare Group, Kaohsiung, Taiwan.; School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.; Graduate Institute of Biomedical Science, China Medical University, Taichung City, Taiwan.; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan., Kuo WW; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan, ROC. wwkuo@mail.cmu.edu.tw.; School of pharmacy, China Medical University, Taichung, Taiwan, ROC. wwkuo@mail.cmu.edu.tw.
Source: Journal of translational medicine [J Transl Med] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB-DPP4 signaling.
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  Data: <searchLink fieldCode="AU" term="%22Ng+SC%22">Ng SC</searchLink>; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Kao+SW%22">Kao SW</searchLink>; Department of Orthopedic Surgery, Chung-Shan Medical University Hospital, Taichung, Taiwan, ROC.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Chen+CJ%22">Chen CJ</searchLink>; Division of Breast Surgery, Department of Surgery, China Medical University Hospital, Taichung, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Lin+SZ%22">Lin SZ</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ROC.; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Hsieh+DJ%22">Hsieh DJ</searchLink>; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Kuo+CH%22">Kuo CH</searchLink>; Laboratory of Exercise Biochemistry, Department of Health and Physical Education, The Education University of Hong Kong, Hong Kong SAR, China.; Faculty of Sport Science, The University of Jordan, Amman, Jordan.; School of Physical Education, Suzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Lin+KH%22">Lin KH</searchLink>; College of Medicine, China Medical University, Taichung, Taiwan ROC.; Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan ROC.<br /><searchLink fieldCode="AU" term="%22Huang+CY%22">Huang CY</searchLink>; Center for Molecular Medicine in Traditional Chinese Medicine, E-Da Hospital, E-Da Healthcare Group, Kaohsiung, Taiwan.; School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.; Graduate Institute of Biomedical Science, China Medical University, Taichung City, Taiwan.; Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+WW%22">Kuo WW</searchLink>; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan, ROC. wwkuo@mail.cmu.edu.tw.; School of pharmacy, China Medical University, Taichung, Taiwan, ROC. wwkuo@mail.cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Jun 18. <i>Date of Electronic Publication: </i>2026 Jun 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08445-y
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        Text: English
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      – TitleFull: HIF-1α attenuates ferroptosis-associated dermal fibroblast senescence via modulation of NF-κB-DPP4 signaling.
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              M: 06
              Text: 2026 Jun 18
              Type: published
              Y: 2026
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