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Is There Potential Clinical Utility in Reporting Variants of Uncertain Significance From Prenatal Sequencing?

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Title: Is There Potential Clinical Utility in Reporting Variants of Uncertain Significance From Prenatal Sequencing?
Authors: Gibbs A; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Braham R; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Ramachandran V; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Roberts R; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Willison C; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Ashraf T; Department of Clinical Genetics, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Cobben J; Centre for Fetal Care, Queen Charlotte Hospital, ICHT NHS & Imperial College, London, UK., Gardham A; Department of Clinical Genetics, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Holder-Espinasse M; Department of Clinical Genetics, Guy's Hospital, London, UK., Homfray T; Department of Medical Genetics, St George's University of London, London, UK., Mehta SG; Department of Clinical Genetics, Addenbrooke's Hospital, Cambridge, UK., Tapon D; Queen Charlotte's & Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK., Vasudevan P; Department of Clinical Genetics, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK., Chandler NJ; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
Source: Prenatal diagnosis [Prenat Diagn] 2026 Jun 18. Date of Electronic Publication: 2026 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 8106540 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0223 (Electronic) Linking ISSN: 01973851 NLM ISO Abbreviation: Prenat Diagn Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Is There Potential Clinical Utility in Reporting Variants of Uncertain Significance From Prenatal Sequencing?
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  Data: <searchLink fieldCode="AU" term="%22Gibbs+A%22">Gibbs A</searchLink>; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Braham+R%22">Braham R</searchLink>; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Ramachandran+V%22">Ramachandran V</searchLink>; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Willison+C%22">Willison C</searchLink>; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Ashraf+T%22">Ashraf T</searchLink>; Department of Clinical Genetics, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Cobben+J%22">Cobben J</searchLink>; Centre for Fetal Care, Queen Charlotte Hospital, ICHT NHS & Imperial College, London, UK.<br /><searchLink fieldCode="AU" term="%22Gardham+A%22">Gardham A</searchLink>; Department of Clinical Genetics, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Holder-Espinasse+M%22">Holder-Espinasse M</searchLink>; Department of Clinical Genetics, Guy's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Homfray+T%22">Homfray T</searchLink>; Department of Medical Genetics, St George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mehta+SG%22">Mehta SG</searchLink>; Department of Clinical Genetics, Addenbrooke's Hospital, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tapon+D%22">Tapon D</searchLink>; Queen Charlotte's & Chelsea Hospital, Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Vasudevan+P%22">Vasudevan P</searchLink>; Department of Clinical Genetics, University Hospitals of Leicester, Leicester Royal Infirmary, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Chandler+NJ%22">Chandler NJ</searchLink>; NHS North Thames Genomic Laboratory Hub, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
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  Data: <searchLink fieldCode="JN" term="%228106540%22">Prenatal diagnosis</searchLink> [Prenat Diagn] 2026 Jun 18. <i>Date of Electronic Publication: </i>2026 Jun 18.
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