The pterocarpan (+)-PTC modulates cytoskeletal proteins and induces apoptosis in metastatic castration-resistant prostate cancer: a proteomic perspective.

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Title: The pterocarpan (+)-PTC modulates cytoskeletal proteins and induces apoptosis in metastatic castration-resistant prostate cancer: a proteomic perspective.
Authors: de Brito Vieira Neto J; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., Moraes de Farias K; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Federal University of Ceará, Fortaleza, Brazil., Alves Sales SL; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., Melo VB; Drug Research and Development Center, Postgraduate Program in Translational Medicine, Federal University of Ceará, Fortaleza, Brazil., Nascimento Macêdo SM; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., Koscky Paier CR; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., Bezerra MJ; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Drug Research and Development Center, Postgraduate Program in Translational Medicine, Federal University of Ceará, Fortaleza, Brazil., Moura AA; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Federal University of Ceará, Fortaleza, Brazil.; Department of Animal Science, Federal University of Ceará, Fortaleza, Ceará, Brazil., Carvalho HF; Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, Brazil., Domingos de Sousa F; Center for Experimental Biology, Universidade de Fortaleza, Fortaleza, Brazil., Aquino A; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil., de Oliveira Monteiro AC; Graduate Program in Medical Sciences, Experimental Biology Center, University of Fortaleza, Fortaleza, Brazil., Martins-de-Souza D; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil.; D'Or Institute for Research and Education (IDOR), SãoPaulo, Brazil.; INCT in Modelling Human Complex Diseases With 3D Platforms (Model3D), Conselho Nacional de Desenvolvimento Científico e Tecnológico, SãoPaulo, Brazil., Banwell MG; Institute for Advanced and Applied Chemical Synthesis, Jinan University, Zhuhai, China., Miranda Furtado CL; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Pessoa C; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Federal University of Ceará, Fortaleza, Brazil.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jun 03; Vol. 17, pp. 1770249. Date of Electronic Publication: 2026 Jun 03 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: The pterocarpan (+)-PTC modulates cytoskeletal proteins and induces apoptosis in metastatic castration-resistant prostate cancer: a proteomic perspective.
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  Data: <searchLink fieldCode="AU" term="%22de+Brito+Vieira+Neto+J%22">de Brito Vieira Neto J</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Moraes+de+Farias+K%22">Moraes de Farias K</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Federal University of Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+Sales+SL%22">Alves Sales SL</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Melo+VB%22">Melo VB</searchLink>; Drug Research and Development Center, Postgraduate Program in Translational Medicine, Federal University of Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Nascimento+Macêdo+SM%22">Nascimento Macêdo SM</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Koscky+Paier+CR%22">Koscky Paier CR</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Bezerra+MJ%22">Bezerra MJ</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Drug Research and Development Center, Postgraduate Program in Translational Medicine, Federal University of Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Moura+AA%22">Moura AA</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Federal University of Ceará, Fortaleza, Brazil.; Department of Animal Science, Federal University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Carvalho+HF%22">Carvalho HF</searchLink>; Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Domingos+de+Sousa+F%22">Domingos de Sousa F</searchLink>; Center for Experimental Biology, Universidade de Fortaleza, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Aquino+A%22">Aquino A</searchLink>; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+Monteiro+AC%22">de Oliveira Monteiro AC</searchLink>; Graduate Program in Medical Sciences, Experimental Biology Center, University of Fortaleza, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins-de-Souza+D%22">Martins-de-Souza D</searchLink>; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil.; D'Or Institute for Research and Education (IDOR), SãoPaulo, Brazil.; INCT in Modelling Human Complex Diseases With 3D Platforms (Model3D), Conselho Nacional de Desenvolvimento Científico e Tecnológico, SãoPaulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Banwell+MG%22">Banwell MG</searchLink>; Institute for Advanced and Applied Chemical Synthesis, Jinan University, Zhuhai, China.<br /><searchLink fieldCode="AU" term="%22Miranda+Furtado+CL%22">Miranda Furtado CL</searchLink>; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.<br /><searchLink fieldCode="AU" term="%22Pessoa+C%22">Pessoa C</searchLink>; Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.; Programa de Pós-Graduação em Biotecnologia, Rede Nordeste de Biotecnologia, Federal University of Ceará, Fortaleza, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Jun 03; Vol. 17, pp. 1770249. <i>Date of Electronic Publication: </i>2026 Jun 03 (<i>Print Publication: </i>2026).
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