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Sebetralstat for on-demand treatment of hereditary angioedema: A pooled analysis of placebo-controlled clinical trials.

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Title: Sebetralstat for on-demand treatment of hereditary angioedema: A pooled analysis of placebo-controlled clinical trials.
Authors: Aygören-Pürsün E; University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Cohn DM; Amsterdam UMC Location AMC, Amsterdam, Netherlands., Agmon-Levin N; Clinical Immunology, Angioedema and Allergy Institute, The Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv, Israel., Banerji A; Professor of Medicine, Harvard Medical School, Clinical Director, Allergy and Immunology, Massachusetts General Hospital, Boston, Massachusetts, United States., Bernstein JA; University of Cincinnati College of Medicine, Division of Rheumatology, Allergy and Immunology, Advanced Allergy Services and Bernstein Clinical Research Center, Cincinnati, Ohio, United States., Busse P; Icahn School of Medicine at Mount Sinai, New York, New York, United States., Cancian M; Departmental Unit of Allergology, University Hospital of Padua, Padua, Italy., de Castro ED; Allergy and Clinical Immunology Department, Centro Hospitalar Universitário de S. João EPE, Porto, Portugal.; Public Health and Forensic Sciences and Medical Education Department, Faculty of Medicine, University of Porto, Porto, Portugal., Farkas H; Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Grivcheva-Panovska V; ACARE North Macedonia, PHI University Clinic of Dermatology, Ss Cyril and Methodius Skopje University, Skopje, Republic of North Macedonia., Hagin D; Allergy and Clinical Immunology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Hakl R; Department of Clinical Immunology and Allergology, St. Annés University Hospital in Brno, and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Honda D; Department of Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan., Kessel A; Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel., Kinaciyan T; Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel., Ifaad; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Kurowski M; Department of Immunology and Allergy, Medical University of Łódź, Łódź, Poland., Li HH; Institute for Asthma and Allergy, Chevy Chase, Maryland, United States., Lleonart R; Allergology Department, Bellvitge University Hospital, Barcelona, Spain., Longhurst HJ; Department of Medicine, University of Auckland and Department of Immunology, Auckland City Hospital, Auckland, New Zealand., Lumry WR; AARA Research Center, Dallas, Texas, United States., Magerl M; Angioedema Center of Reference and Excellence (ACARE), Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Martinez-Saguer I; Hemophilia Center Rhine Main, Frankfurt, Germany., Melamed I; IMMUNOe Research Center, Centennial, Colorado, United States., Psarros F; Allergy Department, Naval Hospital, Athens, Greece., Savic S; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom., Soteres DF; Asthma & Allergy Associates, Colorado Springs, Colorado, Department of Internal Medicine, Division of Allergy and Immunology, University of Colorado Health Sciences Center, Denver, CO, United States., Staevska M; Department of Allergology, Medical University of Sofia, Clinic of Allergology, University Hospital 'Alexandrovska' Sofia, Sofia, Bulgaria., Stobiecki M; Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland., Wedner HJ; Division of Allergy and Immunology, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States., Zanichelli A; Operative Unit of Medicine, Angioedema Center, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.; Department of Biomedical Science for Health, University of Milan, Milan, Italy., Hao J; KalVista Pharmaceuticals, Inc., Framingham, Massachusetts, United States., Patil K; KalVista Pharmaceuticals, Inc., Framingham, Massachusetts, United States., Iverson M; KalVista Pharmaceuticals, Inc., Framingham, Massachusetts, United States., Owiredu-Yeboa S; KalVista Pharmaceuticals, Inc., Salisbury, United Kingdom., Smith MD; KalVista Pharmaceuticals, Inc., Framingham, Massachusetts, United States., Yea CM; KalVista Pharmaceuticals, Inc., Salisbury, United Kingdom., Audhya PK; KalVista Pharmaceuticals, Inc., Framingham, Massachusetts, United States., Riedl MA; Division of Allergy and Immunology, University of California - San Diego, La Jolla, California, United States., Kiani-Alikhan S; Royal Free London NHS Foundation Trust, London, United Kingdom., Maurer M; Angioedema Center of Reference and Excellence (ACARE), Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Source: The World Allergy Organization journal [World Allergy Organ J] 2026 Jun 09; Vol. 19 (7), pp. 101401. Date of Electronic Publication: 2026 Jun 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101481283 Publication Model: eCollection Cited Medium: Print ISSN: 1939-4551 (Print) Linking ISSN: 19394551 NLM ISO Abbreviation: World Allergy Organ J Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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