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Early versus late starting of direct oral anticoagulants after breakthrough ischemic stroke: A target trial analysis from the ASPERA-R study.

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Title: Early versus late starting of direct oral anticoagulants after breakthrough ischemic stroke: A target trial analysis from the ASPERA-R study.
Authors: D'Anna L; Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Foschi M; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.; Department of Neurosciences, Stroke Unit-Neurology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy., Gabriele F; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Ornello R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Zini A; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy., Paolucci M; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy., Forlivesi S; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy., Gentile M; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy., Urbinati G; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy., Cascio Rizzo A; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Sessa M; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Schwarz G; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Tortorella R; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Prandin G; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste, Trieste, Italy., Banerjee S; Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK., Desai G; Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK., Pantoni L; Department of Biomedical and Clinical Sciences, Neuroscience Research Center, University of Milan, Milan, Italy.; Department of Neurorehabilitation Sciences, Casa di Cura Igea, Milan, Italy., Mele F; Neurology Unit, University Hospital Luigi Sacco, Milan, Italy., Scopelliti G; Neurology Unit, University Hospital Luigi Sacco, Milan, Italy., Cova I; Neurology Unit, University Hospital Luigi Sacco, Milan, Italy., Valente M; Clinical Neurology, DMED, University of Udine, Udine, Italy., Maisano D; Clinical Neurology, DMED, University of Udine, Udine, Italy., Antonelli L; Clinical Neurology, DMED, University of Udine, Udine, Italy., Bagnato MR; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy., Di Mauro G; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy., Bernocchi F; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy., Di Donna MG; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy., Casolla B; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France., Mazloum MP; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France., Kacani K; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France., Noufel-Anis D; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France., González-Martin L; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain., Rigual R; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain., Fuentes B; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain., Hervás C; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain., Candelaresi P; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy., Andreone V; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy., De Mase A; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy., Spina E; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy., Aguiar de Sousa D; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal.; Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Almudi Souza M; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal., Fior A; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal., Serôdio M; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal., Caliandro P; Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.; Department of Neuroscience, Sensory Organs, and Thorax, UOC Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Zauli A; Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.; Department of Neuroscience, Sensory Organs, and Thorax, UOC Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Reale G; UOC Neuroriabilitazione ad Alta Intensità, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Abdelalim A; Department of Neurology, Faculty of Medicine, Cairo University Stroke Center, Cairo University, Cairo, Egypt., Ahmed S; Department of Neurology, Faculty of Medicine, Cairo University Stroke Center, Cairo University, Cairo, Egypt., Ismail SA; Department of Neurology, Faculty of Medicine, Cairo University Stroke Center, Cairo University, Cairo, Egypt., Zhang L; Department of Neurology, St George's University Hospital, London, UK., Latimer T; Department of Neurology, St George's University Hospital, London, UK., Elboghday M; Department of Neurology, St George's University Hospital, London, UK., ElBassiouny A; Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Roushdy T; Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Shokri H; Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ferrari F; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Department of Emergency Neurology and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy., Loizzo ND; Department of Emergency Neurology and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy., Mazzacane F; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Department of Emergency Neurology and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy., Guarino M; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Barone V; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy., Forti P; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Rinaldi G; S.C. Neurologia, Ospedale Di Venere, Bari, Italy., Rossi M; S.C. Neurologia, Ospedale Di Venere, Bari, Italy., Laterza V; S.C. Neurologia, Ospedale Di Venere, Bari, Italy., Frisullo G; Emergency Neurology, Department of Neuroscience, Sensory Organs, and Thorax, Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Rizzo PA; Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy., Broccolini A; Stroke Unit, Department of Neuroscience, Sensory Organs, and Thorax, Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Mannino M; UOC Neurologia e Stroke Unit, AOOR Villa Sofia-Cervello, Palermo, Italy., Terruso V; UOC Neurologia e Stroke Unit, AOOR Villa Sofia-Cervello, Palermo, Italy., Caggiula M; UOC Neurologia e Stroke Unit, PO Vito Fazzi, Lecce, Italy., Scalise S; UOC Neurologia e Stroke Unit, PO Vito Fazzi, Lecce, Italy., Fonseca AC; Neurology Department, Faculdade de Medicina, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal., Antunes B; Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal., Budincevic H; Department of Neurology, Sveti Duh University Hospital, Zagreb, Croatia.; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia., Crnac P; Department of Neurology, Sveti Duh University Hospital, Zagreb, Croatia., Viticchi G; Neurological Clinic, Marche Polytechnic University, Ancona, Italy., Silvestrini M; Neurological Clinic, Marche Polytechnic University, Ancona, Italy., Barba L; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Otto M; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Musienko V; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Lochner P; Department of Neurology, Saarland University Medical Center, Homburg, Germany., Landau B; Department of Neurology, Saarland University Medical Center, Homburg, Germany., Buddha S; Department of Stroke Medicine, Southmead Hospital, North Bristol NHS Trust, Bristol, UK., Khalil R; Department of Stroke Medicine, Southmead Hospital, North Bristol NHS Trust, Bristol, UK., Piscaglia MG; Department of Neurosciences, Stroke Unit-Neurology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy., Miserocchi LM; Department of Neurosciences, Stroke Unit-Neurology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy., Zedde M; Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Emilia, Italy., Nasreldein A; Department of Neurology, Assiut University, Assiut, Egypt., Vinciguerra L; Department of Neurology and Stroke Unit, ASST Crema Hospital, Crema, Italy., Costa L; Department of Neurology, Local Health Unit of Alto Minho, Viana do Castelo, Portugal., ElsaidElsayed A; Neurology and Neurointervention Department, Kobry El Kobba Medical Complex, Cairo, Egypt., Al Banna M; Department of Neurology, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia., Tudisco L; Stroke Unit, Careggi University Hospital, Florence, Italy., Mosconi MG; Department of Internal and Cardiovascular Medicine, Santa Maria della Misericordia Hospital, Perugia, Italy., Merlino G; SOSD Stroke Unit, Udine University Hospital, Udine, Italy., Polymeris A; Neurology and Stroke Center, Universitatsspital Basel, Basel, Switzerland., De Santis F; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Sacco S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Source: International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2026 Jun 19, pp. 17474930261463051. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101274068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4949 (Electronic) Linking ISSN: 17474930 NLM ISO Abbreviation: Int J Stroke Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42318991
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
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  Data: Early versus late starting of direct oral anticoagulants after breakthrough ischemic stroke: A target trial analysis from the ASPERA-R study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22D'Anna+L%22">D'Anna L</searchLink>; Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Foschi+M%22">Foschi M</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.; Department of Neurosciences, Stroke Unit-Neurology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.<br /><searchLink fieldCode="AU" term="%22Gabriele+F%22">Gabriele F</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Ornello+R%22">Ornello R</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Zini+A%22">Zini A</searchLink>; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Paolucci+M%22">Paolucci M</searchLink>; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Forlivesi+S%22">Forlivesi S</searchLink>; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Gentile+M%22">Gentile M</searchLink>; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Urbinati+G%22">Urbinati G</searchLink>; Department of Neurology and Stroke Center, IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Cascio+Rizzo+A%22">Cascio Rizzo A</searchLink>; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sessa+M%22">Sessa M</searchLink>; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Schwarz+G%22">Schwarz G</searchLink>; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tortorella+R%22">Tortorella R</searchLink>; Department of Neurology and Stroke Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Prandin+G%22">Prandin G</searchLink>; Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Banerjee+S%22">Banerjee S</searchLink>; Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Desai+G%22">Desai G</searchLink>; Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Pantoni+L%22">Pantoni L</searchLink>; Department of Biomedical and Clinical Sciences, Neuroscience Research Center, University of Milan, Milan, Italy.; Department of Neurorehabilitation Sciences, Casa di Cura Igea, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mele+F%22">Mele F</searchLink>; Neurology Unit, University Hospital Luigi Sacco, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Scopelliti+G%22">Scopelliti G</searchLink>; Neurology Unit, University Hospital Luigi Sacco, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cova+I%22">Cova I</searchLink>; Neurology Unit, University Hospital Luigi Sacco, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Valente+M%22">Valente M</searchLink>; Clinical Neurology, DMED, University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Maisano+D%22">Maisano D</searchLink>; Clinical Neurology, DMED, University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Antonelli+L%22">Antonelli L</searchLink>; Clinical Neurology, DMED, University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Bagnato+MR%22">Bagnato MR</searchLink>; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Mauro+G%22">Di Mauro G</searchLink>; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy.<br /><searchLink fieldCode="AU" term="%22Bernocchi+F%22">Bernocchi F</searchLink>; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Donna+MG%22">Di Donna MG</searchLink>; UOC Stroke Unit e Neurologia, Ospedale Fabrizio Spaziani, Frosinone, Italy.<br /><searchLink fieldCode="AU" term="%22Casolla+B%22">Casolla B</searchLink>; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France.<br /><searchLink fieldCode="AU" term="%22Mazloum+MP%22">Mazloum MP</searchLink>; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France.<br /><searchLink fieldCode="AU" term="%22Kacani+K%22">Kacani K</searchLink>; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France.<br /><searchLink fieldCode="AU" term="%22Noufel-Anis+D%22">Noufel-Anis D</searchLink>; Stroke Unit, CHU Pasteur 2, Université Cote d'Azur, UMR2CA URRIS, Nice, France.<br /><searchLink fieldCode="AU" term="%22González-Martin+L%22">González-Martin L</searchLink>; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rigual+R%22">Rigual R</searchLink>; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fuentes+B%22">Fuentes B</searchLink>; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Hervás+C%22">Hervás C</searchLink>; Stroke Center and Department of Neurology, Hospital La Paz Institute for Health Research, La Paz University Hospital-Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Candelaresi+P%22">Candelaresi P</searchLink>; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Andreone+V%22">Andreone V</searchLink>; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22De+Mase+A%22">De Mase A</searchLink>; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Spina+E%22">Spina E</searchLink>; UOC Neurologia e Stroke Unit, AORN Cardarelli, Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Aguiar+de+Sousa+D%22">Aguiar de Sousa D</searchLink>; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal.; Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Almudi+Souza+M%22">Almudi Souza M</searchLink>; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Fior+A%22">Fior A</searchLink>; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Serôdio+M%22">Serôdio M</searchLink>; Department of Neurosciences, Stroke Center, Centro Hospitalar Universitário de Lisboa Central, ULS de São José, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Caliandro+P%22">Caliandro P</searchLink>; Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.; Department of Neuroscience, Sensory Organs, and Thorax, UOC Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zauli+A%22">Zauli A</searchLink>; Department of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.; Department of Neuroscience, Sensory Organs, and Thorax, UOC Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Reale+G%22">Reale G</searchLink>; UOC Neuroriabilitazione ad Alta Intensità, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Abdelalim+A%22">Abdelalim A</searchLink>; Department of Neurology, Faculty of Medicine, Cairo University Stroke Center, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Ahmed+S%22">Ahmed S</searchLink>; Department of Neurology, Faculty of Medicine, Cairo University Stroke Center, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Ismail+SA%22">Ismail SA</searchLink>; Department of Neurology, Faculty of Medicine, Cairo University Stroke Center, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Neurology, St George's University Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Latimer+T%22">Latimer T</searchLink>; Department of Neurology, St George's University Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Elboghday+M%22">Elboghday M</searchLink>; Department of Neurology, St George's University Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22ElBassiouny+A%22">ElBassiouny A</searchLink>; Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Roushdy+T%22">Roushdy T</searchLink>; Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Shokri+H%22">Shokri H</searchLink>; Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Ferrari+F%22">Ferrari F</searchLink>; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Department of Emergency Neurology and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Loizzo+ND%22">Loizzo ND</searchLink>; Department of Emergency Neurology and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzacane+F%22">Mazzacane F</searchLink>; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Department of Emergency Neurology and Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Guarino+M%22">Guarino M</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Barone+V%22">Barone V</searchLink>; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Forti+P%22">Forti P</searchLink>; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Rinaldi+G%22">Rinaldi G</searchLink>; S.C. Neurologia, Ospedale Di Venere, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+M%22">Rossi M</searchLink>; S.C. Neurologia, Ospedale Di Venere, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Laterza+V%22">Laterza V</searchLink>; S.C. Neurologia, Ospedale Di Venere, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Frisullo+G%22">Frisullo G</searchLink>; Emergency Neurology, Department of Neuroscience, Sensory Organs, and Thorax, Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzo+PA%22">Rizzo PA</searchLink>; Catholic University of the Sacred Heart, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Broccolini+A%22">Broccolini A</searchLink>; Stroke Unit, Department of Neuroscience, Sensory Organs, and Thorax, Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mannino+M%22">Mannino M</searchLink>; UOC Neurologia e Stroke Unit, AOOR Villa Sofia-Cervello, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Terruso+V%22">Terruso V</searchLink>; UOC Neurologia e Stroke Unit, AOOR Villa Sofia-Cervello, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Caggiula+M%22">Caggiula M</searchLink>; UOC Neurologia e Stroke Unit, PO Vito Fazzi, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Scalise+S%22">Scalise S</searchLink>; UOC Neurologia e Stroke Unit, PO Vito Fazzi, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Fonseca+AC%22">Fonseca AC</searchLink>; Neurology Department, Faculdade de Medicina, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Antunes+B%22">Antunes B</searchLink>; Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Budincevic+H%22">Budincevic H</searchLink>; Department of Neurology, Sveti Duh University Hospital, Zagreb, Croatia.; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.<br /><searchLink fieldCode="AU" term="%22Crnac+P%22">Crnac P</searchLink>; Department of Neurology, Sveti Duh University Hospital, Zagreb, Croatia.<br /><searchLink fieldCode="AU" term="%22Viticchi+G%22">Viticchi G</searchLink>; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Silvestrini+M%22">Silvestrini M</searchLink>; Neurological Clinic, Marche Polytechnic University, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Barba+L%22">Barba L</searchLink>; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Otto+M%22">Otto M</searchLink>; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Musienko+V%22">Musienko V</searchLink>; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Lochner+P%22">Lochner P</searchLink>; Department of Neurology, Saarland University Medical Center, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Landau+B%22">Landau B</searchLink>; Department of Neurology, Saarland University Medical Center, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Buddha+S%22">Buddha S</searchLink>; Department of Stroke Medicine, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Khalil+R%22">Khalil R</searchLink>; Department of Stroke Medicine, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Piscaglia+MG%22">Piscaglia MG</searchLink>; Department of Neurosciences, Stroke Unit-Neurology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.<br /><searchLink fieldCode="AU" term="%22Miserocchi+LM%22">Miserocchi LM</searchLink>; Department of Neurosciences, Stroke Unit-Neurology Unit, Santa Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy.<br /><searchLink fieldCode="AU" term="%22Zedde+M%22">Zedde M</searchLink>; Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Nasreldein+A%22">Nasreldein A</searchLink>; Department of Neurology, Assiut University, Assiut, Egypt.<br /><searchLink fieldCode="AU" term="%22Vinciguerra+L%22">Vinciguerra L</searchLink>; Department of Neurology and Stroke Unit, ASST Crema Hospital, Crema, Italy.<br /><searchLink fieldCode="AU" term="%22Costa+L%22">Costa L</searchLink>; Department of Neurology, Local Health Unit of Alto Minho, Viana do Castelo, Portugal.<br /><searchLink fieldCode="AU" term="%22ElsaidElsayed+A%22">ElsaidElsayed A</searchLink>; Neurology and Neurointervention Department, Kobry El Kobba Medical Complex, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Al+Banna+M%22">Al Banna M</searchLink>; Department of Neurology, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Tudisco+L%22">Tudisco L</searchLink>; Stroke Unit, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Mosconi+MG%22">Mosconi MG</searchLink>; Department of Internal and Cardiovascular Medicine, Santa Maria della Misericordia Hospital, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Merlino+G%22">Merlino G</searchLink>; SOSD Stroke Unit, Udine University Hospital, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Polymeris+A%22">Polymeris A</searchLink>; Neurology and Stroke Center, Universitatsspital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22De+Santis+F%22">De Santis F</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Sacco+S%22">Sacco S</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101274068%22">International journal of stroke : official journal of the International Stroke Society</searchLink> [Int J Stroke] 2026 Jun 19, pp. 17474930261463051. <i>Date of Electronic Publication: </i>2026 Jun 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274068 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1747-4949 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217474930%22">17474930 </searchLink><i>NLM ISO Abbreviation: </i>Int J Stroke <i>Subsets: </i>MEDLINE
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      – TitleFull: Early versus late starting of direct oral anticoagulants after breakthrough ischemic stroke: A target trial analysis from the ASPERA-R study.
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              Text: 2026 Jun 19
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