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Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.

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Title: Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.
Authors: Bhagchandani SH; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Ehrenzeller S; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Pires IS; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Center for Engineered Therapeutics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA., Chaudhary N; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA., Booth CJ; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Kwon DI; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Koutsioumpa C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Baker CA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Laxton C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Santos Guedes de Sá K; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Matthews C; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Gill P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Li S; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Olszowka A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Hudak A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Fischer S; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Bayarri-Olmos R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Hooper WB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA., Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Source: Science immunology [Sci Immunol] 2026 Jun 19; Vol. 11 (120), pp. eaea6419. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.
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  Data: <searchLink fieldCode="AU" term="%22Bhagchandani+SH%22">Bhagchandani SH</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Ehrenzeller+S%22">Ehrenzeller S</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Pires+IS%22">Pires IS</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Center for Engineered Therapeutics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Chaudhary+N%22">Chaudhary N</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Booth+CJ%22">Booth CJ</searchLink>; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Kwon+DI%22">Kwon DI</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Koutsioumpa+C%22">Koutsioumpa C</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Baker+CA%22">Baker CA</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Laxton+C%22">Laxton C</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Santos+Guedes+de+Sá+K%22">Santos Guedes de Sá K</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Matthews+C%22">Matthews C</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Gill+P%22">Gill P</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Olszowka+A%22">Olszowka A</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Hudak+A%22">Hudak A</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+S%22">Fischer S</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Bayarri-Olmos+R%22">Bayarri-Olmos R</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Hooper+WB%22">Hooper WB</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.<br /><searchLink fieldCode="AU" term="%22Iwasaki+A%22">Iwasaki A</searchLink>; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.; Center for Infection & Immunity, Yale University School of Medicine, New Haven, CT 06520, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
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