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Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP.

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Title: Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP.
Authors: Robin N; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Barra NG; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Foley KP; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Li YE; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Tamrakar AK; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, India., Patoli D; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, F-69007, Lyon, France., Rebalka IA; Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Cree T; Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia., Bibby K; Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia., Nguyen K; Department of Biology, York University, Canada., Davis R; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Chan DY; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Duggan BM; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Henriksbo BD; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Borges ME; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Kukje Zada D; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Fang H; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Marko DM; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Gregorevic P; Centre for Muscle Research Department of Anatomy and Physiology, The University of Melbourne, Melbourne 3010, Australia.; Department of Neurology, The University of Washington School of Medicine, Seattle, WA 98195, USA., Watt KI; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia.; Centre for Muscle Research Department of Anatomy and Physiology, The University of Melbourne, Melbourne 3010, Australia., Mills RJ; Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.; Department of Pediatrics, The University of Melbourne, Melbourne, VIC, Australia., Sweeney G; Department of Biology, York University, Canada., Hawke TJ; Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada., Py BF; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, F-69007, Lyon, France., Schertzer JD; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Source: Science advances [Sci Adv] 2026 Jun 19; Vol. 12 (25), pp. eadz3612. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP.
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  Data: <searchLink fieldCode="AU" term="%22Robin+N%22">Robin N</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Barra+NG%22">Barra NG</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Foley+KP%22">Foley KP</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Li+YE%22">Li YE</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Tamrakar+AK%22">Tamrakar AK</searchLink>; Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow, India.<br /><searchLink fieldCode="AU" term="%22Patoli+D%22">Patoli D</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Rebalka+IA%22">Rebalka IA</searchLink>; Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Cree+T%22">Cree T</searchLink>; Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Bibby+K%22">Bibby K</searchLink>; Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+K%22">Nguyen K</searchLink>; Department of Biology, York University, Canada.<br /><searchLink fieldCode="AU" term="%22Davis+R%22">Davis R</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Chan+DY%22">Chan DY</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Duggan+BM%22">Duggan BM</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Henriksbo+BD%22">Henriksbo BD</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Borges+ME%22">Borges ME</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Kukje+Zada+D%22">Kukje Zada D</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Fang+H%22">Fang H</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Marko+DM%22">Marko DM</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Gregorevic+P%22">Gregorevic P</searchLink>; Centre for Muscle Research Department of Anatomy and Physiology, The University of Melbourne, Melbourne 3010, Australia.; Department of Neurology, The University of Washington School of Medicine, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Watt+KI%22">Watt KI</searchLink>; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia.; Centre for Muscle Research Department of Anatomy and Physiology, The University of Melbourne, Melbourne 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Mills+RJ%22">Mills RJ</searchLink>; Murdoch Children's Research Institute, The Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria 3052, Australia.; Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children's Research Institute, Melbourne, Australia.; School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.; Department of Pediatrics, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sweeney+G%22">Sweeney G</searchLink>; Department of Biology, York University, Canada.<br /><searchLink fieldCode="AU" term="%22Hawke+TJ%22">Hawke TJ</searchLink>; Department of Pathology and Molecular Medicine, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.<br /><searchLink fieldCode="AU" term="%22Py+BF%22">Py BF</searchLink>; CIRI, Centre International de Recherche en Infectiologie, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Schertzer+JD%22">Schertzer JD</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.; Centre for Metabolism, Obesity and Diabetes Research, McMaster University, 1200 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
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