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Should triple inhaled therapy be initiated earlier in the disease course of COPD to modify long-term outcomes, including mortality, exacerbations, and cardiovascular risk?

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Title: Should triple inhaled therapy be initiated earlier in the disease course of COPD to modify long-term outcomes, including mortality, exacerbations, and cardiovascular risk?
Authors: Quaranta VN; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy., Dragonieri S; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy. Electronic address: silvano.dragonieri@uniba.it., Cosentino G; Respiratory Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Science University of Milan, Milan, Italy., Motta V; Respiratory Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Science University of Milan, Milan, Italy., Signorello JC; Division of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, L. Sacco Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy., Di Stefano G; Pulmonology Unit, University Hospital 'Policlinico G. Rodolico - San Marco', Catania, Italy., Ciasullo E; Pneumology and Intermediate Respiratory Care Unit, AORN A. Cardarelli, Naples, Italy., Radovanovic D; Division of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, L. Sacco Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy., Carpagnano GE; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy., Santus P; Department of Health Science University of Milan, Milan, Italy.
Source: Respiratory medicine [Respir Med] 2026 Jun 19; Vol. 261, pp. 108965. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-3064
DOI:10.1016/j.rmed.2026.108965