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Should triple inhaled therapy be initiated earlier in the disease course of COPD to modify long-term outcomes, including mortality, exacerbations, and cardiovascular risk?

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Title: Should triple inhaled therapy be initiated earlier in the disease course of COPD to modify long-term outcomes, including mortality, exacerbations, and cardiovascular risk?
Authors: Quaranta VN; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy., Dragonieri S; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy. Electronic address: silvano.dragonieri@uniba.it., Cosentino G; Respiratory Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Science University of Milan, Milan, Italy., Motta V; Respiratory Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Science University of Milan, Milan, Italy., Signorello JC; Division of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, L. Sacco Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy., Di Stefano G; Pulmonology Unit, University Hospital 'Policlinico G. Rodolico - San Marco', Catania, Italy., Ciasullo E; Pneumology and Intermediate Respiratory Care Unit, AORN A. Cardarelli, Naples, Italy., Radovanovic D; Division of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, L. Sacco Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy., Carpagnano GE; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy., Santus P; Department of Health Science University of Milan, Milan, Italy.
Source: Respiratory medicine [Respir Med] 2026 Jun 19; Vol. 261, pp. 108965. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 8908438 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3064 (Electronic) Linking ISSN: 09546111 NLM ISO Abbreviation: Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Should triple inhaled therapy be initiated earlier in the disease course of COPD to modify long-term outcomes, including mortality, exacerbations, and cardiovascular risk?
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  Data: <searchLink fieldCode="AU" term="%22Quaranta+VN%22">Quaranta VN</searchLink>; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Dragonieri+S%22">Dragonieri S</searchLink>; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy. Electronic address: silvano.dragonieri@uniba.it.<br /><searchLink fieldCode="AU" term="%22Cosentino+G%22">Cosentino G</searchLink>; Respiratory Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Science University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Motta+V%22">Motta V</searchLink>; Respiratory Medicine Unit, ASST Papa Giovanni XXIII, Bergamo, Italy; Department of Health Science University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Signorello+JC%22">Signorello JC</searchLink>; Division of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, L. Sacco Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Stefano+G%22">Di Stefano G</searchLink>; Pulmonology Unit, University Hospital 'Policlinico G. Rodolico - San Marco', Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Ciasullo+E%22">Ciasullo E</searchLink>; Pneumology and Intermediate Respiratory Care Unit, AORN A. Cardarelli, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Radovanovic+D%22">Radovanovic D</searchLink>; Division of Respiratory Diseases, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, L. Sacco Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Carpagnano+GE%22">Carpagnano GE</searchLink>; Institute of Respiratory Diseases, Department of Translational Biomedicine and Neuroscience, University 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Santus+P%22">Santus P</searchLink>; Department of Health Science University of Milan, Milan, Italy.
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  Data: <searchLink fieldCode="JN" term="%228908438%22">Respiratory medicine</searchLink> [Respir Med] 2026 Jun 19; Vol. 261, pp. 108965. <i>Date of Electronic Publication: </i>2026 Jun 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8908438 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-3064 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209546111%22">09546111 </searchLink><i>NLM ISO Abbreviation: </i>Respir Med <i>Subsets: </i>MEDLINE
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