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Differential cytokine architecture in patients treated with CART19 versus CART22.

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Title: Differential cytokine architecture in patients treated with CART19 versus CART22.
Authors: Diorio C; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA DIORIOC@chop.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Shraim R; Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Thadi A; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Frank-Kamenetskii A; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Uppuluri L; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Klinghoffer H; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Martinez Z; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Babu A; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Myers RM; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Fraietta JA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Hughes A; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sussman J; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Xu J; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., McClory SE; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Mueller K; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Perazzelli J; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Vella LA; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Henrickson SE; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Ruella M; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Behrens EM; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., DiNofia AM; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Burkhardt JK; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Maude SL; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Canna S; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Tan K; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Grupp S; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Teachey DT; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Jun 19; Vol. 14 (6). Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
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  Data: Differential cytokine architecture in patients treated with CART19 versus CART22.
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  Data: <searchLink fieldCode="AU" term="%22Diorio+C%22">Diorio C</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA DIORIOC@chop.edu.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Shraim+R%22">Shraim R</searchLink>; Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Thadi+A%22">Thadi A</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Frank-Kamenetskii+A%22">Frank-Kamenetskii A</searchLink>; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Uppuluri+L%22">Uppuluri L</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Klinghoffer+H%22">Klinghoffer H</searchLink>; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+Z%22">Martinez Z</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Babu+A%22">Babu A</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Myers+RM%22">Myers RM</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Fraietta+JA%22">Fraietta JA</searchLink>; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hughes+A%22">Hughes A</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sussman+J%22">Sussman J</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22McClory+SE%22">McClory SE</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+K%22">Mueller K</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Perazzelli+J%22">Perazzelli J</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Vella+LA%22">Vella LA</searchLink>; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Henrickson+SE%22">Henrickson SE</searchLink>; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Immunology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Ruella+M%22">Ruella M</searchLink>; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Behrens+EM%22">Behrens EM</searchLink>; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22DiNofia+AM%22">DiNofia AM</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Burkhardt+JK%22">Burkhardt JK</searchLink>; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Maude+SL%22">Maude SL</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Canna+S%22">Canna S</searchLink>; Immune Dysregulation Program, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Tan+K%22">Tan K</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Grupp+S%22">Grupp S</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Teachey+DT%22">Teachey DT</searchLink>; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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