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ATF4 coordinates amino acid and nucleotide synthesis with selective protein translation to ensure proper DNA replication timing in leukemia cells.

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Title: ATF4 coordinates amino acid and nucleotide synthesis with selective protein translation to ensure proper DNA replication timing in leukemia cells.
Authors: Huhn JM; Fox Chase Cancer Center, Philadelphia, PA, USA.; Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Valin L; Washington University School of Medicine, Saint Louis, MO, USA., Basse M; Washington University School of Medicine, Saint Louis, MO, USA., Sokei J; Washington University School of Medicine, Saint Louis, MO, USA., Gabriel N; Washington University School of Medicine, Saint Louis, MO, USA., Martinez E; Fox Chase Cancer Center, Philadelphia, PA, USA., Kanefsky JS; Fox Chase Cancer Center, Philadelphia, PA, USA.; Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Stransky S; Albert Einstein College of Medicine, New York, NY, USA., Dorrance A; Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA., Garzon R; Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA., Di Marcantonio D; Fox Chase Cancer Center, Philadelphia, PA, USA., Skorski T; Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA., Goldman AR; Wistar Institute, Philadelphia, PA, USA., Tang HY; Wistar Institute, Philadelphia, PA, USA., Cortellazzi S; University of Parma, Parma, Italy., di Martino O; University of Parma, Parma, Italy., Krais J; Washington University School of Medicine, Saint Louis, MO, USA., Sidoli S; Albert Einstein College of Medicine, New York, NY, USA., Ferraro F; Washington University School of Medicine, Saint Louis, MO, USA. ferrarof@wustl.edu., Wiest DL; Fox Chase Cancer Center, Philadelphia, PA, USA. david.wiest@fccc.edu., Sykes SM; Washington University School of Medicine, Saint Louis, MO, USA. s.m.sykes@wustl.edu.
Source: Nature communications [Nat Commun] 2026 Jun 20. Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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