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Replication origin firing capacity indicates ATR inhibitor sensitivity.

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Title: Replication origin firing capacity indicates ATR inhibitor sensitivity.
Authors: Lumeau A; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Pfuderer PL; Department of Pathology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, Li Ka Shing Centre, Cambridge, UK., Scarth JA; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Maniati E; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Guscott MA; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Shaikh N; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Copley FB; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Gerdes H; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., De Angelis S; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Alard EL; Centre for Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Wang J; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Cutillas PR; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK., Mardakheh FK; Department of Biochemistry, University of Oxford, Oxford, UK., Boemo MA; Department of Pathology, University of Cambridge, Cambridge, UK.; Department of Genetics, University of Cambridge, Cambridge, UK., Forment JV; DDR Biology, Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK., McClelland SE; Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, UK. s.mcclelland@qmul.ac.uk.
Source: Nature communications [Nat Commun] 2026 Jun 19. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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