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Early induction of the Rho-GEF ECT2 drives MEK/ERK oncogenic signaling in pancreatic ductal adenocarcinoma.

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Title: Early induction of the Rho-GEF ECT2 drives MEK/ERK oncogenic signaling in pancreatic ductal adenocarcinoma.
Authors: Al-Qasrawi D; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA., Murray NN; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Argo RA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Fleming Martinez AK; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA., Pandya P; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Clarke AY; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; University of North Florida, Jacksonville, FL, USA., Winter KC; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Krishna M; Department of Pathology/Lab Medicine, Mayo Clinic, Jacksonville, FL, USA., Storz P; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA., Murray NR; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA., Justilien V; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA. Justilien.verline@mayo.edu.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA. Justilien.verline@mayo.edu.
Source: Oncogene [Oncogene] 2026 Aug; Vol. 45 (30), pp. 3053-3068. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
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  Data: Early induction of the Rho-GEF ECT2 drives MEK/ERK oncogenic signaling in pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Al-Qasrawi+D%22">Al-Qasrawi D</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Murray+NN%22">Murray NN</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Argo+RA%22">Argo RA</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Fleming+Martinez+AK%22">Fleming Martinez AK</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pandya+P%22">Pandya P</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Clarke+AY%22">Clarke AY</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; University of North Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Winter+KC%22">Winter KC</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Krishna+M%22">Krishna M</searchLink>; Department of Pathology/Lab Medicine, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Storz+P%22">Storz P</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Murray+NR%22">Murray NR</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Justilien+V%22">Justilien V</searchLink>; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA. Justilien.verline@mayo.edu.; Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL, USA. Justilien.verline@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2026 Aug; Vol. 45 (30), pp. 3053-3068. <i>Date of Electronic Publication: </i>2026 Jun 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8711562 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5594 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209509232%22">09509232 </searchLink><i>NLM ISO Abbreviation: </i>Oncogene <i>Subsets: </i>MEDLINE
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              Text: 2026 Aug
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