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Tumor cell Jagged-1 promotes regional lymphatic metastasis and predicts recurrence in node-positive breast cancer.

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Title: Tumor cell Jagged-1 promotes regional lymphatic metastasis and predicts recurrence in node-positive breast cancer.
Authors: Gordon B; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Yale School of Medicine, Yale University, New Haven, CT, USA.; University of Illinois Cancer Center, Chicago, IL, USA., Swaminathan B; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA., Youn SW; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA., Obacz NA; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA., Vadakath R; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Center for Cancer Research, Lymphoid Malignancies Branch, National Institutes of Health, Bethesda, MD, USA., Teneqexhi P; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA., Alvarez-Lopez I; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.; Gipuzkoa Cancer Unit, OSI Donostialdea-Onkologikoa Foundation, Donostia-San Sebastian, Spain., Rezola M; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.; Gipuzkoa Cancer Unit, OSI Donostialdea-Onkologikoa Foundation, Donostia-San Sebastian, Spain., Manzano S; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain., Telletxea Z; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain., Xu Z; University of Illinois Cancer Center, Chicago, IL, USA.; Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USA.; Biostatistics Shared Resource Core, University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL, USA., Chen Z; University of Illinois Cancer Center, Chicago, IL, USA.; Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USA.; Biostatistics Shared Resource Core, University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL, USA., Er EE; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA., Naiche LA; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA., M Caffarel M; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.; Ikerbasque Basque Foundation for Science, Bilbao, Spain., Kitajewski J; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA. kitaj@uic.edu.; University of Illinois Cancer Center, Chicago, IL, USA. kitaj@uic.edu.
Source: Breast cancer research : BCR [Breast Cancer Res] 2026 Jun 19. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE
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  Data: Tumor cell Jagged-1 promotes regional lymphatic metastasis and predicts recurrence in node-positive breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Gordon+B%22">Gordon B</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Yale School of Medicine, Yale University, New Haven, CT, USA.; University of Illinois Cancer Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Swaminathan+B%22">Swaminathan B</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Youn+SW%22">Youn SW</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Obacz+NA%22">Obacz NA</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Vadakath+R%22">Vadakath R</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; Center for Cancer Research, Lymphoid Malignancies Branch, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Teneqexhi+P%22">Teneqexhi P</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez-Lopez+I%22">Alvarez-Lopez I</searchLink>; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.; Gipuzkoa Cancer Unit, OSI Donostialdea-Onkologikoa Foundation, Donostia-San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Rezola+M%22">Rezola M</searchLink>; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.; Gipuzkoa Cancer Unit, OSI Donostialdea-Onkologikoa Foundation, Donostia-San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Manzano+S%22">Manzano S</searchLink>; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Telletxea+Z%22">Telletxea Z</searchLink>; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; University of Illinois Cancer Center, Chicago, IL, USA.; Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USA.; Biostatistics Shared Resource Core, University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; University of Illinois Cancer Center, Chicago, IL, USA.; Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL, USA.; Biostatistics Shared Resource Core, University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Er+EE%22">Er EE</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Naiche+LA%22">Naiche LA</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA.; University of Illinois Cancer Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22M+Caffarel+M%22">M Caffarel M</searchLink>; Biogipuzkoa (previously known as Biodonostia) Health Research Institute, Donostia-San Sebastian, Spain.; Ikerbasque Basque Foundation for Science, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Kitajewski+J%22">Kitajewski J</searchLink>; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, IL, USA. kitaj@uic.edu.; University of Illinois Cancer Center, Chicago, IL, USA. kitaj@uic.edu.
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