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Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.

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Title: Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.
Authors: Milicic L; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia., Vacher M; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia.; CSIRO Health and Biosecurity, Australian E-Health Research Centre, Floreat, WA, 6014, Australia., Doré V; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, VIC, Australia.; Australian E-Health Research Centre, CSIRO, Parkville, VIC, 3052, Australia., Bourgeat P; Australian E-Health Research Centre, CSIRO, Herston, QLD, 4029, Australia., Shishegar R; Australian E-Health Research Centre, CSIRO, Parkville, VIC, 3052, Australia.; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia., Doecke JD; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Australian E-Health Research Centre, CSIRO, Herston, QLD, 4029, Australia., Maruff P; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.; Cogstate Ltd., Melbourne, VIC, Australia., Rowe CC; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, VIC, Australia.; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia., Villemagne VL; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Porter T; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia.; Curtin Medical School, Curtin University, Bentley, WA, 6102, Australia., Laws SM; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia. s.laws@ecu.edu.au.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia. s.laws@ecu.edu.au.; Curtin Medical School, Curtin University, Bentley, WA, 6102, Australia. s.laws@ecu.edu.au.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative (ADNI), Australian Imaging Biomarkers, Lifestyle (AIBL) Study
Source: GeroScience [Geroscience] 2026 Jun 20. Date of Electronic Publication: 2026 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.
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  Data: <searchLink fieldCode="AU" term="%22Milicic+L%22">Milicic L</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia.<br /><searchLink fieldCode="AU" term="%22Vacher+M%22">Vacher M</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia.; CSIRO Health and Biosecurity, Australian E-Health Research Centre, Floreat, WA, 6014, Australia.<br /><searchLink fieldCode="AU" term="%22Doré+V%22">Doré V</searchLink>; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, VIC, Australia.; Australian E-Health Research Centre, CSIRO, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Bourgeat+P%22">Bourgeat P</searchLink>; Australian E-Health Research Centre, CSIRO, Herston, QLD, 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Shishegar+R%22">Shishegar R</searchLink>; Australian E-Health Research Centre, CSIRO, Parkville, VIC, 3052, Australia.; School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Doecke+JD%22">Doecke JD</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Australian E-Health Research Centre, CSIRO, Herston, QLD, 4029, Australia.<br /><searchLink fieldCode="AU" term="%22Maruff+P%22">Maruff P</searchLink>; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.; Cogstate Ltd., Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Rowe+CC%22">Rowe CC</searchLink>; Department of Molecular Imaging & Therapy and Centre for PET, Austin Health, Heidelberg, VIC, Australia.; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Villemagne+VL%22">Villemagne VL</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Porter+T%22">Porter T</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia.; Curtin Medical School, Curtin University, Bentley, WA, 6102, Australia.<br /><searchLink fieldCode="AU" term="%22Laws+SM%22">Laws SM</searchLink>; Centre for Precision Health, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia. s.laws@ecu.edu.au.; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia. s.laws@ecu.edu.au.; Curtin Medical School, Curtin University, Bentley, WA, 6102, Australia. s.laws@ecu.edu.au.
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  Data: <searchLink fieldCode="CA" term="%22Alzheimer%27s+Disease+Neuroimaging+Initiative+%28ADNI%29%22">Alzheimer’s Disease Neuroimaging Initiative (ADNI)</searchLink><br /><searchLink fieldCode="CA" term="%22Australian+Imaging+Biomarkers%2C+Lifestyle+%28AIBL%29+Study%22">Australian Imaging Biomarkers, Lifestyle (AIBL) Study</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Jun 20. <i>Date of Electronic Publication: </i>2026 Jun 20.
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              Text: 2026 Jun 20
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