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Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology.

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Title: Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology.
Authors: Richter FC; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Keszei Z; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Viczenczova C; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Baumgartner M; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Colaço HG; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Siller M; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Holnsteiner L; Institute of Immunology, University Hospital Essen, Essen, Germany., Baazim H; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Sabri Ülker Center for Metabolic Research, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Hofmann A; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Burrett A; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Schönbichler A; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria., Endler L; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Wong JXE; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Antonio-Herrera L; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Petrenko O; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, and.; Vienna Hepatic Experimental Hemodynamic (HEPEX) Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Ukrainian Institute for Systems Biology and Medicine, Kyiv, Ukraine., Amman F; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Genger JW; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Fuchs CD; Division of Gastroenterology and Hepatology, Department of Medicine III, and., Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Marschall HU; Wallenberg Laboratory and Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Reiberger T; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, and.; Vienna Hepatic Experimental Hemodynamic (HEPEX) Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Lang KS; Institute of Immunology, University Hospital Essen, Essen, Germany., Campbell C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Trauner M; Division of Gastroenterology and Hepatology, Department of Medicine III, and., Bergthaler A; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Source: JCI insight [JCI Insight] 2026 Jun 22; Vol. 11 (12). Date of Electronic Publication: 2026 Jun 22 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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  Data: Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology.
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  Data: <searchLink fieldCode="AU" term="%22Richter+FC%22">Richter FC</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Keszei+Z%22">Keszei Z</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Viczenczova+C%22">Viczenczova C</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Baumgartner+M%22">Baumgartner M</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Colaço+HG%22">Colaço HG</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Siller+M%22">Siller M</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Holnsteiner+L%22">Holnsteiner L</searchLink>; Institute of Immunology, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Baazim+H%22">Baazim H</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Sabri Ülker Center for Metabolic Research, Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hofmann+A%22">Hofmann A</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Burrett+A%22">Burrett A</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schönbichler+A%22">Schönbichler A</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Endler+L%22">Endler L</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wong+JXE%22">Wong JXE</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Antonio-Herrera+L%22">Antonio-Herrera L</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Petrenko+O%22">Petrenko O</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, and.; Vienna Hepatic Experimental Hemodynamic (HEPEX) Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; Ukrainian Institute for Systems Biology and Medicine, Kyiv, Ukraine.<br /><searchLink fieldCode="AU" term="%22Amman+F%22">Amman F</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Genger+JW%22">Genger JW</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Fuchs+CD%22">Fuchs CD</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, and.<br /><searchLink fieldCode="AU" term="%22Scharnagl+H%22">Scharnagl H</searchLink>; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Marschall+HU%22">Marschall HU</searchLink>; Wallenberg Laboratory and Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Reiberger+T%22">Reiberger T</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Division of Gastroenterology and Hepatology, Department of Medicine III, and.; Vienna Hepatic Experimental Hemodynamic (HEPEX) Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lang+KS%22">Lang KS</searchLink>; Institute of Immunology, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Campbell+C%22">Campbell C</searchLink>; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Trauner+M%22">Trauner M</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, and.<br /><searchLink fieldCode="AU" term="%22Bergthaler+A%22">Bergthaler A</searchLink>; Department of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Jun 22; Vol. 11 (12). <i>Date of Electronic Publication: </i>2026 Jun 22 (<i>Print Publication: </i>2026).
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