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Longitudinal brain structural changes during clozapine treatment: associations with neuroreceptor architecture and clinical response.

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Title: Longitudinal brain structural changes during clozapine treatment: associations with neuroreceptor architecture and clinical response.
Authors: King B; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Cannon DM; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway., Crossley NA; Department of Psychiatry, Pontificia, Universidad Catolica de Chile, Santiago, Chile.; Centro de Interés Nacional para Investigación e Innovación en Niñez, Adolescencia, Resiliencia y Adversidad (IINARA), Santiago, Chile., Gonzalez-Valderrama A; School of Medicine, Finis Terrae University, Santiago, Chile.; Dr José Horwitz Barack Psychiatric Institute, Santiago Chile., Hallahan B; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway., Jung WH; Department of Psychology, Gachon University, Gyeonggi-do, Republic of Korea., Kempton MJ; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Kim S; Department of Psychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Seoul, Republic of Korea., Lawrence AJ; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., MacCabe JH; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway.; Department of Psychiatry, Pontificia, Universidad Catolica de Chile, Santiago, Chile.; Centro de Interés Nacional para Investigación e Innovación en Niñez, Adolescencia, Resiliencia y Adversidad (IINARA), Santiago, Chile.; School of Medicine, Finis Terrae University, Santiago, Chile.; Dr José Horwitz Barack Psychiatric Institute, Santiago Chile.; Department of Psychology, Gachon University, Gyeonggi-do, Republic of Korea.; Department of Psychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Seoul, Republic of Korea.; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo.; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.; University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.; Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., McDonald C; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway., Mena C; Centro de Interés Nacional para Investigación e Innovación en Niñez, Adolescencia, Resiliencia y Adversidad (IINARA), Santiago, Chile.; Dr José Horwitz Barack Psychiatric Institute, Santiago Chile., Nakajima S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo., Papale A; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Raminfard S; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Sarpal DK; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Sim H; Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea., Tronchin G; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway., Tuominen L; University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada., Kim E; Department of Psychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Seoul, Republic of Korea.; Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.; Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea., Egerton A; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jun 10. Date of Electronic Publication: 2026 Jun 10.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Longitudinal brain structural changes during clozapine treatment: associations with neuroreceptor architecture and clinical response.
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  Data: <searchLink fieldCode="AU" term="%22King+B%22">King B</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cannon+DM%22">Cannon DM</searchLink>; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway.<br /><searchLink fieldCode="AU" term="%22Crossley+NA%22">Crossley NA</searchLink>; Department of Psychiatry, Pontificia, Universidad Catolica de Chile, Santiago, Chile.; Centro de Interés Nacional para Investigación e Innovación en Niñez, Adolescencia, Resiliencia y Adversidad (IINARA), Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Valderrama+A%22">Gonzalez-Valderrama A</searchLink>; School of Medicine, Finis Terrae University, Santiago, Chile.; Dr José Horwitz Barack Psychiatric Institute, Santiago Chile.<br /><searchLink fieldCode="AU" term="%22Hallahan+B%22">Hallahan B</searchLink>; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway.<br /><searchLink fieldCode="AU" term="%22Jung+WH%22">Jung WH</searchLink>; Department of Psychology, Gachon University, Gyeonggi-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kempton+MJ%22">Kempton MJ</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Psychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lawrence+AJ%22">Lawrence AJ</searchLink>; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22MacCabe+JH%22">MacCabe JH</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway.; Department of Psychiatry, Pontificia, Universidad Catolica de Chile, Santiago, Chile.; Centro de Interés Nacional para Investigación e Innovación en Niñez, Adolescencia, Resiliencia y Adversidad (IINARA), Santiago, Chile.; School of Medicine, Finis Terrae University, Santiago, Chile.; Dr José Horwitz Barack Psychiatric Institute, Santiago Chile.; Department of Psychology, Gachon University, Gyeonggi-do, Republic of Korea.; Department of Psychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Seoul, Republic of Korea.; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo.; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.; University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.; Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22McDonald+C%22">McDonald C</searchLink>; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway.<br /><searchLink fieldCode="AU" term="%22Mena+C%22">Mena C</searchLink>; Centro de Interés Nacional para Investigación e Innovación en Niñez, Adolescencia, Resiliencia y Adversidad (IINARA), Santiago, Chile.; Dr José Horwitz Barack Psychiatric Institute, Santiago Chile.<br /><searchLink fieldCode="AU" term="%22Nakajima+S%22">Nakajima S</searchLink>; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo.<br /><searchLink fieldCode="AU" term="%22Papale+A%22">Papale A</searchLink>; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Raminfard+S%22">Raminfard S</searchLink>; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sarpal+DK%22">Sarpal DK</searchLink>; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sim+H%22">Sim H</searchLink>; Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Tronchin+G%22">Tronchin G</searchLink>; Clinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition and Genomics (NICOG), Galway.<br /><searchLink fieldCode="AU" term="%22Tuominen+L%22">Tuominen L</searchLink>; University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+E%22">Kim E</searchLink>; Department of Psychiatry, Seoul National University Bundang Hospital, Gyeonggi-do, Seoul, Republic of Korea.; Department of Brain & Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.; Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Egerton+A%22">Egerton A</searchLink>; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
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        Value: 10.64898/2026.06.06.26354980
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