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Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk.

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Title: Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk.
Authors: Genner RM; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Department of Biology, Johns Hopkins University, Baltimore, MD USA., Meredith M; UC Santa Cruz Genomics Institute, Santa Cruz, CA USA.; DataTecnica LLC, Washington, DC USA., Daida K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA., Moller A; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Weller C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; DataTecnica LLC, Washington, DC USA., Ayuketah A; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Jerez PA; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Global Parkinson's Genetics Program (GP2), Chevy Chase, MD USA., Akeson S; Department of Bioengineering, Northeastern University, Boston, MA USA., Malik L; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Baker B; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Kouam C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Paquette K; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Catching A; DataTecnica LLC, Washington, DC USA., Bromberek S; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Hu F; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Reed X; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA., Marenco S; Human Brain Collection Core, Division of Intramural Research, National Institute of Mental Health, NIH, Bethesda, MD USA., Auluck P; Human Brain Collection Core, Division of Intramural Research, National Institute of Mental Health, NIH, Bethesda, MD USA., Mandal A; Human Brain Collection Core, Division of Intramural Research, National Institute of Mental Health, NIH, Bethesda, MD USA., Paten B; UC Santa Cruz Genomics Institute, Santa Cruz, CA USA., Gibbs JR; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA., Jain M; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Department of Bioengineering, Northeastern University, Boston, MA USA., Cookson MR; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA., Singleton AB; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.; Global Parkinson's Genetics Program (GP2), Chevy Chase, MD USA., Nalls M; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; DataTecnica LLC, Washington, DC USA., Blauwendraat C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA., Billingsley KJ; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.
Source: NPJ dementia [NPJ Dement] 2026; Vol. 2 (1), pp. 45. Date of Electronic Publication: 2026 Jun 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 9918993995206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3005-1940 (Electronic) Linking ISSN: 30051940 NLM ISO Abbreviation: NPJ Dement Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Haplotype-resolved DNA methylation at the APOE locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk.
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  Data: <searchLink fieldCode="AU" term="%22Genner+RM%22">Genner RM</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Department of Biology, Johns Hopkins University, Baltimore, MD USA.<br /><searchLink fieldCode="AU" term="%22Meredith+M%22">Meredith M</searchLink>; UC Santa Cruz Genomics Institute, Santa Cruz, CA USA.; DataTecnica LLC, Washington, DC USA.<br /><searchLink fieldCode="AU" term="%22Daida+K%22">Daida K</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Moller+A%22">Moller A</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Weller+C%22">Weller C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; DataTecnica LLC, Washington, DC USA.<br /><searchLink fieldCode="AU" term="%22Ayuketah+A%22">Ayuketah A</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Jerez+PA%22">Jerez PA</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.; Global Parkinson's Genetics Program (GP2), Chevy Chase, MD USA.<br /><searchLink fieldCode="AU" term="%22Akeson+S%22">Akeson S</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA USA.<br /><searchLink fieldCode="AU" term="%22Malik+L%22">Malik L</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Baker+B%22">Baker B</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Kouam+C%22">Kouam C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Paquette+K%22">Paquette K</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Catching+A%22">Catching A</searchLink>; DataTecnica LLC, Washington, DC USA.<br /><searchLink fieldCode="AU" term="%22Bromberek+S%22">Bromberek S</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Reed+X%22">Reed X</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Marenco+S%22">Marenco S</searchLink>; Human Brain Collection Core, Division of Intramural Research, National Institute of Mental Health, NIH, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Auluck+P%22">Auluck P</searchLink>; Human Brain Collection Core, Division of Intramural Research, National Institute of Mental Health, NIH, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Mandal+A%22">Mandal A</searchLink>; Human Brain Collection Core, Division of Intramural Research, National Institute of Mental Health, NIH, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Paten+B%22">Paten B</searchLink>; UC Santa Cruz Genomics Institute, Santa Cruz, CA USA.<br /><searchLink fieldCode="AU" term="%22Gibbs+JR%22">Gibbs JR</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Jain+M%22">Jain M</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Department of Bioengineering, Northeastern University, Boston, MA USA.<br /><searchLink fieldCode="AU" term="%22Cookson+MR%22">Cookson MR</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.; Global Parkinson's Genetics Program (GP2), Chevy Chase, MD USA.<br /><searchLink fieldCode="AU" term="%22Nalls+M%22">Nalls M</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; DataTecnica LLC, Washington, DC USA.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.<br /><searchLink fieldCode="AU" term="%22Billingsley+KJ%22">Billingsley KJ</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD USA.
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