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Decoupling Physisorption from Chemisorption in Clickable Lipid Nanoparticles.

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Title: Decoupling Physisorption from Chemisorption in Clickable Lipid Nanoparticles.
Authors: Brysgel TV; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Hood ED; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Milosavljevic A; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Marzolini N; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Zamora ME; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Wu J; Division of Pulmonary Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Shuvaev VV; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Shuvaeva T; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Kegel M; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Muscat-Rivera J; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Weissman D; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Melamed JR; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Myerson JW; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Brenner JS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Division of Pulmonary Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Nong J; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Source: ACS nanoscience Au [ACS Nanosci Au] 2026 Feb 20; Vol. 6 (3), pp. 348-356. Date of Electronic Publication: 2026 Feb 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9918316881006676 Publication Model: eCollection Cited Medium: Internet ISSN: 2694-2496 (Electronic) Linking ISSN: 26942496 NLM ISO Abbreviation: ACS Nanosci Au Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Brysgel+TV%22">Brysgel TV</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Hood+ED%22">Hood ED</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Milosavljevic+A%22">Milosavljevic A</searchLink>; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Marzolini+N%22">Marzolini N</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Zamora+ME%22">Zamora ME</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Division of Pulmonary Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Shuvaev+VV%22">Shuvaev VV</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Shuvaeva+T%22">Shuvaeva T</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Kegel+M%22">Kegel M</searchLink>; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Muscat-Rivera+J%22">Muscat-Rivera J</searchLink>; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Weissman+D%22">Weissman D</searchLink>; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Melamed+JR%22">Melamed JR</searchLink>; Infectious Diseases Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Myerson+JW%22">Myerson JW</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Brenner+JS%22">Brenner JS</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Division of Pulmonary Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Muzykantov+VR%22">Muzykantov VR</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Nong+J%22">Nong J</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
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        Text: English
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