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Plumbagin sensitizes leukemia cells to cisplatin by promoting oxidative stress, apoptosis, and DNA damage.

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Title: Plumbagin sensitizes leukemia cells to cisplatin by promoting oxidative stress, apoptosis, and DNA damage.
Authors: Chen YN; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Lee JW; Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan., Chien TM; School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Urology, Kaohsiung Gangshan Hospital, Kaohsiung Medical University, Kaohsiung 820111, Taiwan., Yen CH; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Chen BH; Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Chang HW; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.; Center for Cancer Research and Research Center for Molecular Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Source: International journal of medical sciences [Int J Med Sci] 2026 May 29; Vol. 23 (7), pp. 2290-2301. Date of Electronic Publication: 2026 May 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plumbagin sensitizes leukemia cells to cisplatin by promoting oxidative stress, apoptosis, and DNA damage.
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  Data: <searchLink fieldCode="AU" term="%22Chen+YN%22">Chen YN</searchLink>; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+JW%22">Lee JW</searchLink>; Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, Pingtung 912301, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+TM%22">Chien TM</searchLink>; School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Urology, Kaohsiung Gangshan Hospital, Kaohsiung Medical University, Kaohsiung 820111, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+CH%22">Yen CH</searchLink>; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+BH%22">Chen BH</searchLink>; Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+HW%22">Chang HW</searchLink>; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.; Center for Cancer Research and Research Center for Molecular Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101213954%22">International journal of medical sciences</searchLink> [Int J Med Sci] 2026 May 29; Vol. 23 (7), pp. 2290-2301. <i>Date of Electronic Publication: </i>2026 May 29 (<i>Print Publication: </i>2026).
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      – TitleFull: Plumbagin sensitizes leukemia cells to cisplatin by promoting oxidative stress, apoptosis, and DNA damage.
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              Text: 2026 May 29
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