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Prime editing-mediated microhomology enables efficient replacement of large DNA.

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Title: Prime editing-mediated microhomology enables efficient replacement of large DNA.
Authors: Xie Y; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Li P; Xianghu Laboratory, Hangzhou 311231, China., He Z; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Huang H; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Wu D; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Ma Z; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Feng S; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Ran J; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Hou K; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Gao F; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China., Du X; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.; Animal Science Research Office, Sanya Institute of China Agricultural University, Sanya 572024, China., Capecchi MR; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, United States., Wu S; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.; Animal Science Research Office, Sanya Institute of China Agricultural University, Sanya 572024, China.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Jun 22; Vol. 54 (12).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prime editing-mediated microhomology enables efficient replacement of large DNA.
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  Data: <searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Xianghu Laboratory, Hangzhou 311231, China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Wu+D%22">Wu D</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Ma+Z%22">Ma Z</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Feng+S%22">Feng S</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Ran+J%22">Ran J</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Hou+K%22">Hou K</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Gao+F%22">Gao F</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.<br /><searchLink fieldCode="AU" term="%22Du+X%22">Du X</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.; Animal Science Research Office, Sanya Institute of China Agricultural University, Sanya 572024, China.<br /><searchLink fieldCode="AU" term="%22Capecchi+MR%22">Capecchi MR</searchLink>; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, United States.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.; Animal Science Research Office, Sanya Institute of China Agricultural University, Sanya 572024, China.
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              Text: 2026 Jun 22
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