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APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses.

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Title: APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses.
Authors: Zeng Y; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA., Cook N; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA., Yang C; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA., Sivasankaran SK; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA., Fujita M; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA., Gardell ZA; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, California, USA.; Department of Neurology, University of California San Francisco, San Francisco, California, USA., Le Guen Y; Quantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, California, USA., Shigemizu D; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Ozaki K; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Aging Research, Nagoya University Graduate School of Medicine, Nagoya, Japan., Morizono T; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan., Hara N; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Miyashita A; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan., Pottier C; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA., Cruchaga C; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA., Napolioni V; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Macerata, Italy., Corces MR; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, California, USA.; Department of Neurology, University of California San Francisco, San Francisco, California, USA., Menon V; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA., Greicius MD; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Belloy ME; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jun; Vol. 22 (6), pp. e71552.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
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  Data: APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses.
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  Data: <searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Cook+N%22">Cook N</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Sivasankaran+SK%22">Sivasankaran SK</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Fujita+M%22">Fujita M</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Gardell+ZA%22">Gardell ZA</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, California, USA.; Department of Neurology, University of California San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Le+Guen+Y%22">Le Guen Y</searchLink>; Quantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Shigemizu+D%22">Shigemizu D</searchLink>; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Ozaki+K%22">Ozaki K</searchLink>; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.; Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Aging Research, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Morizono+T%22">Morizono T</searchLink>; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Hara+N%22">Hara N</searchLink>; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Miyashita+A%22">Miyashita A</searchLink>; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Ikeuchi+T%22">Ikeuchi T</searchLink>; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Pottier+C%22">Pottier C</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Napolioni+V%22">Napolioni V</searchLink>; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Macerata, Italy.<br /><searchLink fieldCode="AU" term="%22Corces+MR%22">Corces MR</searchLink>; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, California, USA.; Department of Neurology, University of California San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Menon+V%22">Menon V</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Greicius+MD%22">Greicius MD</searchLink>; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Belloy+ME%22">Belloy ME</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.
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