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EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway.

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Title: EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway.
Authors: Scaparone P; University of Turin Turin, TO Italy., Mira A; University of Turin Turin, TO Italy., Cheong TC; Boston Children's Hospital Boston, MA United States., Patrucco E; University of Turin Torino Italy., Ricciuti B; Dana-Farber/Harvard Cancer Center Boston, Massachusetts United States., Gribaudo R; University of Turin Turin, TO Italy., Garbo E; Dana-Farber Cancer Institute Boston, Massachusetts United States., Scardaci R; University of Turin Turin, TO Italy., Savinelli I; University of Turin Turin, TO Italy., Vietti Michelina S; University of Turin Torino Italy., Odintsov I; University of California, San Francisco San Francisco, CA United States., Brea EJ; Dana-Farber Cancer Institute Boston, MA United States., Mignacco R; University of Turin Turin, TO Italy., Blasco RB; Boston Children's Hospital Boston United States., Santamaría D; Consejo Superior de Investigaciones Científicas (CSIC) Salamanca Spain., Voena C; University of Turin Torino Italy., Hofmann MH; Boehringer Ingelheim RCV GmbH & Co KG Vienna Austria., Nadal E; Institut Català d'Oncologia L'Hospitalet de Llobregat, Barcelona Spain., Novello S; University of Turin Orbassano, TO Italy., Awad MM; Memorial Sloan Kettering Cancer Center Boston, Massachusetts United States., Chiarle R; Boston Children's Hospital Boston United States., Ambrogio C; University of Turin Turin, TO Italy.
Source: Cancer discovery [Cancer Discov] 2026 Jun 22. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: EML4-ALK mediates resistance to KRAS G12C inhibition and induces an oncogenic dependency by rewiring signaling through the wild-type RAS pathway.
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  Data: <searchLink fieldCode="AU" term="%22Scaparone+P%22">Scaparone P</searchLink>; University of Turin Turin, TO Italy.<br /><searchLink fieldCode="AU" term="%22Mira+A%22">Mira A</searchLink>; University of Turin Turin, TO Italy.<br /><searchLink fieldCode="AU" term="%22Cheong+TC%22">Cheong TC</searchLink>; Boston Children's Hospital Boston, MA United States.<br /><searchLink fieldCode="AU" term="%22Patrucco+E%22">Patrucco E</searchLink>; University of Turin Torino Italy.<br /><searchLink fieldCode="AU" term="%22Ricciuti+B%22">Ricciuti B</searchLink>; Dana-Farber/Harvard Cancer Center Boston, Massachusetts United States.<br /><searchLink fieldCode="AU" term="%22Gribaudo+R%22">Gribaudo R</searchLink>; University of Turin Turin, TO Italy.<br /><searchLink fieldCode="AU" term="%22Garbo+E%22">Garbo E</searchLink>; Dana-Farber Cancer Institute Boston, Massachusetts United States.<br /><searchLink fieldCode="AU" term="%22Scardaci+R%22">Scardaci R</searchLink>; University of Turin Turin, TO Italy.<br /><searchLink fieldCode="AU" term="%22Savinelli+I%22">Savinelli I</searchLink>; University of Turin Turin, TO Italy.<br /><searchLink fieldCode="AU" term="%22Vietti+Michelina+S%22">Vietti Michelina S</searchLink>; University of Turin Torino Italy.<br /><searchLink fieldCode="AU" term="%22Odintsov+I%22">Odintsov I</searchLink>; University of California, San Francisco San Francisco, CA United States.<br /><searchLink fieldCode="AU" term="%22Brea+EJ%22">Brea EJ</searchLink>; Dana-Farber Cancer Institute Boston, MA United States.<br /><searchLink fieldCode="AU" term="%22Mignacco+R%22">Mignacco R</searchLink>; University of Turin Turin, TO Italy.<br /><searchLink fieldCode="AU" term="%22Blasco+RB%22">Blasco RB</searchLink>; Boston Children's Hospital Boston United States.<br /><searchLink fieldCode="AU" term="%22Santamaría+D%22">Santamaría D</searchLink>; Consejo Superior de Investigaciones Científicas (CSIC) Salamanca Spain.<br /><searchLink fieldCode="AU" term="%22Voena+C%22">Voena C</searchLink>; University of Turin Torino Italy.<br /><searchLink fieldCode="AU" term="%22Hofmann+MH%22">Hofmann MH</searchLink>; Boehringer Ingelheim RCV GmbH & Co KG Vienna Austria.<br /><searchLink fieldCode="AU" term="%22Nadal+E%22">Nadal E</searchLink>; Institut Català d'Oncologia L'Hospitalet de Llobregat, Barcelona Spain.<br /><searchLink fieldCode="AU" term="%22Novello+S%22">Novello S</searchLink>; University of Turin Orbassano, TO Italy.<br /><searchLink fieldCode="AU" term="%22Awad+MM%22">Awad MM</searchLink>; Memorial Sloan Kettering Cancer Center Boston, Massachusetts United States.<br /><searchLink fieldCode="AU" term="%22Chiarle+R%22">Chiarle R</searchLink>; Boston Children's Hospital Boston United States.<br /><searchLink fieldCode="AU" term="%22Ambrogio+C%22">Ambrogio C</searchLink>; University of Turin Turin, TO Italy.
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              Text: 2026 Jun 22
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