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Gabapentinoid Use and Risk of Alzheimer's Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies.

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Title: Gabapentinoid Use and Risk of Alzheimer's Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies.
Authors: da Silva AMP; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil. anderson.mhps@icloud.com., Leite M; Department of Medicine, Santa Marcelina College, São Paulo, SP, Brazil., Menegucci G; Department of Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil., Negreli MFLA; Department of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Valverde MES; Faculty of Medical and Health Sciences FCMS/JF, Juiz de Fora, MG, Brazil., Menezes IR; Department of Medicine, State University of Rio Grande do Norte, Mossoró, RN, Brazil., Gonçalves OR; Department of Medicine, Federal University of Piauí, Teresina, PI, Brazil., da Silva Lapa JD; Department of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil., Noleto G; Neurosurgery Research Division, Afya Uninovafapi University Center, Teresina, PI, Brazil., Santos DH; Department of Neurology, University of São Paulo, São Paulo, SP, Brazil., Duarte FS; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil., Perry G; Department of Neurosciences, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA., de Souza Franco E; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil., de Sousa Maia MB; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil.
Source: Drugs & aging [Drugs Aging] 2026 Jun 22. Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article; Systematic Review
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9102074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1969 (Electronic) Linking ISSN: 1170229X NLM ISO Abbreviation: Drugs Aging Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22da+Silva+AMP%22">da Silva AMP</searchLink>; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil. anderson.mhps@icloud.com.<br /><searchLink fieldCode="AU" term="%22Leite+M%22">Leite M</searchLink>; Department of Medicine, Santa Marcelina College, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Menegucci+G%22">Menegucci G</searchLink>; Department of Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Negreli+MFLA%22">Negreli MFLA</searchLink>; Department of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.<br /><searchLink fieldCode="AU" term="%22Valverde+MES%22">Valverde MES</searchLink>; Faculty of Medical and Health Sciences FCMS/JF, Juiz de Fora, MG, Brazil.<br /><searchLink fieldCode="AU" term="%22Menezes+IR%22">Menezes IR</searchLink>; Department of Medicine, State University of Rio Grande do Norte, Mossoró, RN, Brazil.<br /><searchLink fieldCode="AU" term="%22Gonçalves+OR%22">Gonçalves OR</searchLink>; Department of Medicine, Federal University of Piauí, Teresina, PI, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Lapa+JD%22">da Silva Lapa JD</searchLink>; Department of Medicine, Federal University of Sergipe, Aracaju, SE, Brazil.<br /><searchLink fieldCode="AU" term="%22Noleto+G%22">Noleto G</searchLink>; Neurosurgery Research Division, Afya Uninovafapi University Center, Teresina, PI, Brazil.<br /><searchLink fieldCode="AU" term="%22Santos+DH%22">Santos DH</searchLink>; Department of Neurology, University of São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Duarte+FS%22">Duarte FS</searchLink>; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil.<br /><searchLink fieldCode="AU" term="%22Perry+G%22">Perry G</searchLink>; Department of Neurosciences, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22de+Souza+Franco+E%22">de Souza Franco E</searchLink>; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+Maia+MB%22">de Sousa Maia MB</searchLink>; Department of Physiology and Pharmacology, Federal University of Pernambuco, Av. Professor Moraes Rego Avenue, University City, Recife, PE, 50670-420, Brazil.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>9102074 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-1969 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221170229X%22">1170229X </searchLink><i>NLM ISO Abbreviation: </i>Drugs Aging <i>Subsets: </i>MEDLINE
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