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Probing the limits of genetic recoding using multi-omics-guided evolution.

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Title: Probing the limits of genetic recoding using multi-omics-guided evolution.
Authors: Nyerges A; Department of Genetics, Harvard Medical School, Boston, MA, USA. akos_nyerges@hms.harvard.edu., Chiappino-Pepe A; Department of Genetics, Harvard Medical School, Boston, MA, USA., Budnik B; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Baas-Thomas M; Department of Genetics, Harvard Medical School, Boston, MA, USA., Rhuby E; Department of Genetics, Harvard Medical School, Boston, MA, USA., Flynn R; Department of Genetics, Harvard Medical School, Boston, MA, USA., Yan S; Department of Genetics, Harvard Medical School, Boston, MA, USA.; BGI Research, Shenzhen, China., Ostrov N; Department of Genetics, Harvard Medical School, Boston, MA, USA., Liu M; GenScript USA Inc., Piscataway, NJ, USA., Wang M; GenScript USA Inc., Piscataway, NJ, USA., Zheng Q; GenScript USA Inc., Piscataway, NJ, USA., Hu F; GenScript USA Inc., Piscataway, NJ, USA., Chen K; GenScript USA Inc., Piscataway, NJ, USA., Rudolph A; Department of Genetics, Harvard Medical School, Boston, MA, USA., Chen D; Department of Genetics, Harvard Medical School, Boston, MA, USA., Ahn J; Department of Genetics, Harvard Medical School, Boston, MA, USA., Spencer O; Department of Genetics, Harvard Medical School, Boston, MA, USA., Ayalavarapu V; Department of Genetics, Harvard Medical School, Boston, MA, USA., Tarver A; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Harmon-Smith M; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Hamilton M; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Blaby I; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Yoshikuni Y; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Hajian B; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jin A; GenScript USA Inc., Piscataway, NJ, USA., Kintses B; Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary., Szamel M; Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary., Seregi V; Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary., Shen Y; BGI Research, Shenzhen, China.; BGI Research, Changzhou, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China., Li Z; GenScript USA Inc., Piscataway, NJ, USA., Church GM; Department of Genetics, Harvard Medical School, Boston, MA, USA. gchurch@genetics.med.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. gchurch@genetics.med.harvard.edu.
Source: Nature communications [Nat Commun] 2026 Jun 22; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Nyerges+A%22">Nyerges A</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA. akos_nyerges@hms.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Chiappino-Pepe+A%22">Chiappino-Pepe A</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Budnik+B%22">Budnik B</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Baas-Thomas+M%22">Baas-Thomas M</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rhuby+E%22">Rhuby E</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Flynn+R%22">Flynn R</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yan+S%22">Yan S</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.; BGI Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Ostrov+N%22">Ostrov N</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; GenScript USA Inc., Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; GenScript USA Inc., Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+Q%22">Zheng Q</searchLink>; GenScript USA Inc., Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; GenScript USA Inc., Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; GenScript USA Inc., Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Rudolph+A%22">Rudolph A</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ahn+J%22">Ahn J</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Spencer+O%22">Spencer O</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ayalavarapu+V%22">Ayalavarapu V</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tarver+A%22">Tarver A</searchLink>; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Harmon-Smith+M%22">Harmon-Smith M</searchLink>; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+M%22">Hamilton M</searchLink>; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Blaby+I%22">Blaby I</searchLink>; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yoshikuni+Y%22">Yoshikuni Y</searchLink>; DOE Joint Genome Institute (JGI), Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hajian+B%22">Hajian B</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jin+A%22">Jin A</searchLink>; GenScript USA Inc., Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kintses+B%22">Kintses B</searchLink>; Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Szamel+M%22">Szamel M</searchLink>; Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Seregi+V%22">Seregi V</searchLink>; Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; BGI Research, Shenzhen, China.; BGI Research, Changzhou, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI Research, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; GenScript USA Inc., Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Church+GM%22">Church GM</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA, USA. gchurch@genetics.med.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. gchurch@genetics.med.harvard.edu.
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