Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice.

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Title: Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice.
Authors: Zhang X; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands., Tripathi M; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Goh CT; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Chan CS; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Boelen A; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands., Yen PM; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.; National Heart Centre Singapore, Singapore, Singapore., Singh BK; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Bruinstroop E; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands.; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Source: Aging cell [Aging Cell] 2026 Jul; Vol. 25 (7), pp. e70600.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-9726
DOI:10.1111/acel.70600