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Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice.

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Title: Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice.
Authors: Zhang X; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands., Tripathi M; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Goh CT; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Chan CS; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Boelen A; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands., Yen PM; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.; National Heart Centre Singapore, Singapore, Singapore., Singh BK; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore., Bruinstroop E; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands.; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Source: Aging cell [Aging Cell] 2026 Jul; Vol. 25 (7), pp. e70600.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tripathi+M%22">Tripathi M</searchLink>; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+CT%22">Goh CT</searchLink>; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+CS%22">Chan CS</searchLink>; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Boelen+A%22">Boelen A</searchLink>; Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam Gastroenterology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Yen+PM%22">Yen PM</searchLink>; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.; National Heart Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Singh+BK%22">Singh BK</searchLink>; Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Bruinstroop+E%22">Bruinstroop E</searchLink>; Research Institute Amsterdam Gastroenterology Endocrinology & Metabolism (AGEM), Amsterdam UMC, Amsterdam, the Netherlands.; Department of Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101130839 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-9726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214749718%22">14749718 </searchLink><i>NLM ISO Abbreviation: </i>Aging Cell <i>Subsets: </i>MEDLINE
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        Value: 10.1111/acel.70600
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        Text: English
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      – TitleFull: Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice.
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              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
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