Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction.
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| Title: | Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction. |
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| Authors: | George A; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States., Lan T; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Huber AD; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Dartois V; Center for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.; Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey 07110, United States., Dick T; Center for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States.; Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey 07110, United States.; Department of Microbiology and Immunology, Georgetown University, Washington, District of Columbia 20057, United States., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States., Aldrich CC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States., Freundlich JS; Department of Pharmacology, Physiology, and Neuroscience, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States.; Division of Infectious Disease, Department of Medicine and the Ruy V. Lourenço Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University─New Jersey Medical School, Newark, New Jersey 07103, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2026 Jul 09; Vol. 69 (13), pp. 15858-15871. Date of Electronic Publication: 2026 Jun 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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