Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model.
Saved in:
| Title: | Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model. |
|---|---|
| Authors: | Kapur R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Li L; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Kanumuri R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Padam KSR; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Ramdas B; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Pasala C; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Chiosis G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Palam LR; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Kumar R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Koyama S; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Natarajan P; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Haneline LS; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Yu Z; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Pasupuleti SK; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA. |
| Source: | The Journal of clinical investigation [J Clin Invest] 2026 Jun 23; Vol. 136 (15). Date of Electronic Publication: 2026 Jun 23 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42334870 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kapur+R%22">Kapur R</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kanumuri+R%22">Kanumuri R</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Padam+KSR%22">Padam KSR</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Ramdas+B%22">Ramdas B</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Pasala+C%22">Pasala C</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Chiosis+G%22">Chiosis G</searchLink>; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Palam+LR%22">Palam LR</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+R%22">Kumar R</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Koyama+S%22">Koyama S</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+P%22">Natarajan P</searchLink>; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Haneline+LS%22">Haneline LS</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Yu+Z%22">Yu Z</searchLink>; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Pasupuleti+SK%22">Pasupuleti SK</searchLink>; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2026 Jun 23; Vol. 136 (15). <i>Date of Electronic Publication: </i>2026 Jun 23 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42334870 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1172/JCI202856 Languages: – Code: eng Text: English Titles: – TitleFull: Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kapur R – PersonEntity: Name: NameFull: Li L – PersonEntity: Name: NameFull: Kanumuri R – PersonEntity: Name: NameFull: Padam KSR – PersonEntity: Name: NameFull: Ramdas B – PersonEntity: Name: NameFull: Pasala C – PersonEntity: Name: NameFull: Chiosis G – PersonEntity: Name: NameFull: Palam LR – PersonEntity: Name: NameFull: Kumar R – PersonEntity: Name: NameFull: Koyama S – PersonEntity: Name: NameFull: Natarajan P – PersonEntity: Name: NameFull: Haneline LS – PersonEntity: Name: NameFull: Yu Z – PersonEntity: Name: NameFull: Pasupuleti SK IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 06 Text: 2026 Jun 23 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1558-8238 Numbering: – Type: volume Value: 136 – Type: issue Value: 15 Titles: – TitleFull: The Journal of clinical investigation Type: main |
| ResultId | 1 |
