Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model.
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| Title: | Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model. |
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| Authors: | Kapur R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Li L; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Kanumuri R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Padam KSR; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Ramdas B; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Pasala C; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Chiosis G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Palam LR; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Kumar R; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Koyama S; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Natarajan P; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Haneline LS; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA., Yu Z; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Pasupuleti SK; Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine (IUSM), Indianapolis, Indiana, USA. |
| Source: | The Journal of clinical investigation [J Clin Invest] 2026 Jun 23; Vol. 136 (15). Date of Electronic Publication: 2026 Jun 23 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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