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Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis.

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Title: Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis.
Authors: Gong R; Gastrointestinal Cancer Institute/Pancreatic Disease Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Wang J; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Ren M; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Zhang W; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Ping S; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Jing Y; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Lei K; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Yu Q; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Ma L; Department of Oncology, Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, China., Gao C; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Zhao C; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Fu S; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Xing Y; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Xue J; State Key Laboratory of Systems Medicine for Cancer, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang J; Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China., Sun H; Department of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University, Shijiazhuang, China., Chen J; Clinical Medical College, Hebei University, Department of Urology, Affiliated Hospital of Hebei University, Baoding, China., Zhang S; College of Computer Science and Technology, Ocean University of China, Qingdao, China., Liu M; State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zhao T; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin, China., Saluja A; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Pancreas Center, Center for Interventional Endoscopy, AdventHealth Orlando, Orlando, Florida., Yang Z; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. Electronic address: yangzhan@hebmu.edu.cn., Ren H; Gastrointestinal Cancer Institute/Pancreatic Disease Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. Electronic address: herenrh@163.com.
Source: Gastroenterology [Gastroenterology] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Label: Title
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  Data: Epithelial FOXP3 Orchestrates O-Glycosylated IL6 Secretion to Drive Pancreatic Fibrocarcinogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Gong+R%22">Gong R</searchLink>; Gastrointestinal Cancer Institute/Pancreatic Disease Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Ren+M%22">Ren M</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Ping+S%22">Ping S</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Jing+Y%22">Jing Y</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Lei+K%22">Lei K</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Oncology, Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Gao+C%22">Gao C</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Zhao+C%22">Zhao C</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Fu+S%22">Fu S</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Xing+Y%22">Xing Y</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Xue+J%22">Xue J</searchLink>; State Key Laboratory of Systems Medicine for Cancer, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Department of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Clinical Medical College, Hebei University, Department of Urology, Affiliated Hospital of Hebei University, Baoding, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; College of Computer Science and Technology, Ocean University of China, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; State Key Laboratory of Molecular Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhao+T%22">Zhao T</searchLink>; Pancreas Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Saluja+A%22">Saluja A</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Pancreas Center, Center for Interventional Endoscopy, AdventHealth Orlando, Orlando, Florida.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. Electronic address: yangzhan@hebmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ren+H%22">Ren H</searchLink>; Gastrointestinal Cancer Institute/Pancreatic Disease Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China; Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, Tumor Immunology and Cytotherapy, Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. Electronic address: herenrh@163.com.
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  Data: <searchLink fieldCode="JN" term="%220374630%22">Gastroenterology</searchLink> [Gastroenterology] 2026 Jun 23. <i>Date of Electronic Publication: </i>2026 Jun 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders%22">W.B. Saunders </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0374630 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0012 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200165085%22">00165085 </searchLink><i>NLM ISO Abbreviation: </i>Gastroenterology <i>Subsets: </i>MEDLINE
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        Value: 10.1053/j.gastro.2026.06.007
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