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T1W/T2W Ratio to Assess Brain Microstructural Damage in Multiple Sclerosis: A Multicenter Study.

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Title: T1W/T2W Ratio to Assess Brain Microstructural Damage in Multiple Sclerosis: A Multicenter Study.
Authors: Storelli L; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Preziosa P; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Tedone N; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Gallo A; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Altieri M; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Pantano P; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Piervincenzi C; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., De Stefano N; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Cortese R; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Rocca MA; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy., Filippi M; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy. filippi.massimo@hsr.it.
Corporate Authors: INNI Network
Source: AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Neuroradiology Country of Publication: United States NLM ID: 8003708 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-959X (Electronic) Linking ISSN: 01956108 NLM ISO Abbreviation: AJNR Am J Neuroradiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: T1W/T2W Ratio to Assess Brain Microstructural Damage in Multiple Sclerosis: A Multicenter Study.
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  Data: <searchLink fieldCode="AU" term="%22Storelli+L%22">Storelli L</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Preziosa+P%22">Preziosa P</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tedone+N%22">Tedone N</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gallo+A%22">Gallo A</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Altieri+M%22">Altieri M</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pantano+P%22">Pantano P</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Piervincenzi+C%22">Piervincenzi C</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Stefano+N%22">De Stefano N</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cortese+R%22">Cortese R</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rocca+MA%22">Rocca MA</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Filippi+M%22">Filippi M</searchLink>; From the Neuroimaging Research Unit (L.S., P.Preziosa, N.T., M.A.R., M.F.), Division of Neuroscience, Neurology Unit (P.Preziosa, M.A.R., M.F.), Neurorehabilitation Unit (M.F.), Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Advanced Medical and Surgical Sciences (A.G., M.A.),and 3T MRI-Center, University of Campania 'Luigi Vanvitelli', Naples, Italy; Department of Human Neurosciences (P.Pantano, C.P.), Sapienza University of Rome, Rome, Italy; IRCCS Neuromed (P.Pantano), Pozzilli, Italy; Department of Medicine (N.D.S.), Surgeryand Neuroscience, University of Siena, Siena, Italyand Vita-Salute San Raffaele University (P.Preziosa, N.T., M.A.R., M.F.), Milan, Italy. filippi.massimo@hsr.it.
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