A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function.

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Title: A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function.
Authors: Xue S; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA., Nouraie SM; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Wang J; Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, USA., Li X; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Division of Data-Driven and Digital Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Meyers D; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA., Bleecker ER; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA., Ortega VE; Center for Individualized Medicine, Mayo Clinic, Phoenix, AZ, USA., Castro M; Department of Medicine, University of Kansas Medical Center, Kansas City, KS, USA., Denlinger LC; Division of Pulmonary and Critical Care, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Erzurum S; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Israel E; Department of Medicine, Harvard University School of Medicine, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Woodruff P; School of Medicine, University of California San Francisco, San Francisco, CA, USA., Moore WC; Department of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA., Christenson S; School of Medicine, University of California San Francisco, San Francisco, CA, USA., Fahy J; School of Medicine, University of California San Francisco, San Francisco, CA, USA., Sumino K; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA., Jarjour N; Division of Pulmonary and Critical Care, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Levy B; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA., Wenzel SE; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: swenzel@pitt.edu.
Source: EBioMedicine [EBioMedicine] 2026 Jul; Vol. 129, pp. 106334. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function.
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  Data: <searchLink fieldCode="AU" term="%22Xue+S%22">Xue S</searchLink>; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nouraie+SM%22">Nouraie SM</searchLink>; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Division of Data-Driven and Digital Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Meyers+D%22">Meyers D</searchLink>; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Bleecker+ER%22">Bleecker ER</searchLink>; Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Ortega+VE%22">Ortega VE</searchLink>; Center for Individualized Medicine, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Castro+M%22">Castro M</searchLink>; Department of Medicine, University of Kansas Medical Center, Kansas City, KS, USA.<br /><searchLink fieldCode="AU" term="%22Denlinger+LC%22">Denlinger LC</searchLink>; Division of Pulmonary and Critical Care, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Erzurum+S%22">Erzurum S</searchLink>; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Israel+E%22">Israel E</searchLink>; Department of Medicine, Harvard University School of Medicine, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Woodruff+P%22">Woodruff P</searchLink>; School of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Moore+WC%22">Moore WC</searchLink>; Department of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Christenson+S%22">Christenson S</searchLink>; School of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fahy+J%22">Fahy J</searchLink>; School of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sumino+K%22">Sumino K</searchLink>; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Jarjour+N%22">Jarjour N</searchLink>; Division of Pulmonary and Critical Care, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Levy+B%22">Levy B</searchLink>; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wenzel+SE%22">Wenzel SE</searchLink>; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: swenzel@pitt.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+B%2EV%22">Elsevier B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101647039 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3964 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523964%22">23523964 </searchLink><i>NLM ISO Abbreviation: </i>EBioMedicine <i>Subsets: </i>MEDLINE
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