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Stromal and endothelial transcriptional changes during progression from MGUS to myeloma and after treatment response.

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Title: Stromal and endothelial transcriptional changes during progression from MGUS to myeloma and after treatment response.
Authors: Cenzano I; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Cócera M; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Larrayoz M; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Campos-Dopazo L; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Sanz S; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Bantan A; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Vilas-Zornoza A; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., San-Martin P; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Aguirre-Ruiz P; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Alignani D; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Lopez A; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Sancho González I; Hospital Reina Sofía de Tudela, Tudela, Spain.; Hospital Universitario de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., Ruiz J; Hospital Universitario de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., Ripalda-Cemborain P; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Abengozar-Muela M; Departament of Pathology, Clinica Universidad de Navarra, Pamplona, Spain., Muiños-López E; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Lagani V; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; SDAIA-KAUST Center of Excellence in Data Science and Artificial Intelligence, Thuwal, Saudi Arabia.; Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia., Tegner J; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Computer Science Program, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Unit of Computational Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.; Science for Life Laboratory, Solna, Sweden., Hernáez M; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; Computational Biology Program. Cima Universidad de Navarra, Data Science and Artificial Intelligence Institute (DATAI) Universidad de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., Agirre X; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Ebert B; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Paiva B; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Rodriguez-Otero P; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., Tamariz-Amador LE; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., San-Miguel J; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain., Saez B; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain., Martinez-Climent JA; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain., Calvo IA; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain. icalvoa@unav.es.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain. icalvoa@unav.es., Gomez-Cabrero D; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. david.gomezcabrero@kaust.edu.sa., Prosper F; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain. fprosper@unav.es.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain. fprosper@unav.es.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain. fprosper@unav.es.
Source: Nature communications [Nat Commun] 2026 Jun 23. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Stromal and endothelial transcriptional changes during progression from MGUS to myeloma and after treatment response.
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  Data: <searchLink fieldCode="AU" term="%22Cenzano+I%22">Cenzano I</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Cócera+M%22">Cócera M</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Larrayoz+M%22">Larrayoz M</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Campos-Dopazo+L%22">Campos-Dopazo L</searchLink>; 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Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Aguirre-Ruiz+P%22">Aguirre-Ruiz P</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Alignani+D%22">Alignani D</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lopez+A%22">Lopez A</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Sancho+González+I%22">Sancho González I</searchLink>; 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Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; SDAIA-KAUST Center of Excellence in Data Science and Artificial Intelligence, Thuwal, Saudi Arabia.; Institute of Chemical Biology, Ilia State University, Tbilisi, Georgia.<br /><searchLink fieldCode="AU" term="%22Tegner+J%22">Tegner J</searchLink>; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Computer Science Program, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.; Unit of Computational Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.; Science for Life Laboratory, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Hernáez+M%22">Hernáez M</searchLink>; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; 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Cima Universidad de Navarra, Data Science and Artificial Intelligence Institute (DATAI) Universidad de Navarra, Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Agirre+X%22">Agirre X</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ebert+B%22">Ebert B</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Paiva+B%22">Paiva B</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Otero+P%22">Rodriguez-Otero P</searchLink>; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Tamariz-Amador+LE%22">Tamariz-Amador LE</searchLink>; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22San-Miguel+J%22">San-Miguel J</searchLink>; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Saez+B%22">Saez B</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Climent+JA%22">Martinez-Climent JA</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Calvo+IA%22">Calvo IA</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain. icalvoa@unav.es.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain. icalvoa@unav.es.<br /><searchLink fieldCode="AU" term="%22Gomez-Cabrero+D%22">Gomez-Cabrero D</searchLink>; Division of Biomedical Sciences, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. david.gomezcabrero@kaust.edu.sa.<br /><searchLink fieldCode="AU" term="%22Prosper+F%22">Prosper F</searchLink>; Hematology and Oncology Program, Centre for Applied Medical Research (CIMA), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain. fprosper@unav.es.; Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain. fprosper@unav.es.; Hematology and Cell Therapy Department. Cancer Center Clinica Universidad de Navarra (CCUN), Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain. fprosper@unav.es.
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