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Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.

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Title: Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.
Authors: Ghosh S; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA., Vanwinkle ZM; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA., Bodduluri SR; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA., Juin SK; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA., Kadari M; Department of Microbiology and Immunology, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA., Singh A; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Dryden GW; Department of Medicine, University of Louisville, Louisville, KY, USA., Lawrenz MB; Department of Microbiology and Immunology, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA., Kanneganti TD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rai SN; Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cancer Data Science Center, University of Cincinnati College of Medicine, Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Good M; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kumar P; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Haribabu B; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA., Jala VR; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA. jvrao001@louisville.edu.
Source: Nature communications [Nat Commun] 2026 Jun 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.
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  Data: <searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Vanwinkle+ZM%22">Vanwinkle ZM</searchLink>; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Bodduluri+SR%22">Bodduluri SR</searchLink>; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Juin+SK%22">Juin SK</searchLink>; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Kadari+M%22">Kadari M</searchLink>; Department of Microbiology and Immunology, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Singh+A%22">Singh A</searchLink>; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dryden+GW%22">Dryden GW</searchLink>; Department of Medicine, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Lawrenz+MB%22">Lawrenz MB</searchLink>; Department of Microbiology and Immunology, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Kanneganti+TD%22">Kanneganti TD</searchLink>; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rai+SN%22">Rai SN</searchLink>; Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cancer Data Science Center, University of Cincinnati College of Medicine, Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Good+M%22">Good M</searchLink>; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Haribabu+B%22">Haribabu B</searchLink>; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Jala+VR%22">Jala VR</searchLink>; Department of Microbiology and Immunology, UofL-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, Louisville, KY, USA. jvrao001@louisville.edu.
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