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Rapid boosting increases germinal center responses to sequential vaccines.

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Title: Rapid boosting increases germinal center responses to sequential vaccines.
Authors: Haupt S; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA., Cottrell CA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Zhou X; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Lee JH; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Liguori A; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Alavi N; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Lu D; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Phelps N; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Goodwin D; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA., Ben-Akiva E; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Walsh AA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA., Irvine DJ; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Schief WR; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Moderna Inc., Cambridge, MA, USA., Crotty S; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. shane@lji.org.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA. shane@lji.org.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA. shane@lji.org.
Source: Nature immunology [Nat Immunol] 2026 Jul; Vol. 27 (7), pp. 1476-1489. Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: Rapid boosting increases germinal center responses to sequential vaccines.
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  Data: <searchLink fieldCode="AU" term="%22Haupt+S%22">Haupt S</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cottrell+CA%22">Cottrell CA</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liguori+A%22">Liguori A</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alavi+N%22">Alavi N</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+D%22">Lu D</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Phelps+N%22">Phelps N</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Goodwin+D%22">Goodwin D</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ben-Akiva+E%22">Ben-Akiva E</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+AA%22">Walsh AA</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Irvine+DJ%22">Irvine DJ</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Schief+WR%22">Schief WR</searchLink>; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA.; Moderna Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Crotty+S%22">Crotty S</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. shane@lji.org.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA. shane@lji.org.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA, USA. shane@lji.org.
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  Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2026 Jul; Vol. 27 (7), pp. 1476-1489. <i>Date of Electronic Publication: </i>2026 Jun 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+America+Inc%22">Nature America Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100941354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1529-2916 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215292908%22">15292908 </searchLink><i>NLM ISO Abbreviation: </i>Nat Immunol <i>Subsets: </i>MEDLINE
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