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Spatial analyses implicate high stromal tumour-infiltrating CD8+ lymphocytes as a negative predictive marker for chemotherapy in estrogen receptor-positive breast cancer.

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Title: Spatial analyses implicate high stromal tumour-infiltrating CD8+ lymphocytes as a negative predictive marker for chemotherapy in estrogen receptor-positive breast cancer.
Authors: Kinsella Z; School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland. zakkinsella@rcsi.com., Jahangir CA; UCD Conway Institute, University College Dublin, Dublin, Ireland., Nyarko HN; School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Kalinska-Lysiak D; School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Gonzalez CA; UCD Conway Institute, University College Dublin, Dublin, Ireland., Murphy V; Cancer Trials Ireland, Dublin, Ireland., O'Grady T; Department of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland., Fay J; Department of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland., Sheehan K; Department of Pathology, Royal College of Surgeons in Ireland, Dublin, Ireland., Rahman A; UCD Conway Institute, University College Dublin, Dublin, Ireland., Crown JP; St. Vincent's University Hospital, Dublin, Ireland., Kelly CM; Mater Hospital, Dublin, Ireland., McDade SS; Johnston Cancer Research Centre (JCRC), Queens University Belfast, Belfast, UK., Woods I; Department of Physiology & Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Connolly NMC; Department of Physiology & Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Prehn JHM; Department of Physiology & Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Gallagher WM; UCD Conway Institute, University College Dublin, Dublin, Ireland., O'Connor DP; School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Source: Nature communications [Nat Commun] 2026 Jun 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Spatial analyses implicate high stromal tumour-infiltrating CD8<superscript>+</superscript> lymphocytes as a negative predictive marker for chemotherapy in estrogen receptor-positive breast cancer.
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              Text: 2026 Jun 23
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