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Targeting metabolic dependencies to reverse chemoradiotherapy resistance in colorectal cancer.

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Title: Targeting metabolic dependencies to reverse chemoradiotherapy resistance in colorectal cancer.
Authors: Hellkamp M; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Gertken S; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Buchloh J; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Hellwig JL; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Kowitzke LB; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Duan N; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany., Gaspardo I; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany., Küffer S; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany., Linnebacher M; Molecular Oncology and Immunotherapy, Clinic of General Surgery, University Medical Center Rostock, Rostock, Germany., Ströbel P; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany., Wirth M; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Ellenrieder V; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany., Rieken S; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.; Department of Radiotherapy and Radiooncology, University Medical Center Göttingen, Göttingen, Germany., Gaedcke J; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Clinic for General and Visceral Surgery, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany., Ghadimi M; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany., Wienands J; Institute of Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Schneider G; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.; Institute for Translational Cancer Research and Experimental Cancer Therapy, Technical University Munich, Munich, Germany., Spitzner M; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. melanie.spitzner@med.uni-goettingen.de., Grade M; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. marian.grade@med.uni-goettingen.de.; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany. marian.grade@med.uni-goettingen.de.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany. marian.grade@med.uni-goettingen.de.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Jun 23; Vol. 45 (1). Date of Electronic Publication: 2026 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
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  Data: Targeting metabolic dependencies to reverse chemoradiotherapy resistance in colorectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Hellkamp+M%22">Hellkamp M</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gertken+S%22">Gertken S</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Buchloh+J%22">Buchloh J</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hellwig+JL%22">Hellwig JL</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kowitzke+LB%22">Kowitzke LB</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Duan+N%22">Duan N</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gaspardo+I%22">Gaspardo I</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Küffer+S%22">Küffer S</searchLink>; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Linnebacher+M%22">Linnebacher M</searchLink>; Molecular Oncology and Immunotherapy, Clinic of General Surgery, University Medical Center Rostock, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Ströbel+P%22">Ströbel P</searchLink>; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wirth+M%22">Wirth M</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ellenrieder+V%22">Ellenrieder V</searchLink>; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Rieken+S%22">Rieken S</searchLink>; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.; Department of Radiotherapy and Radiooncology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gaedcke+J%22">Gaedcke J</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Clinic for General and Visceral Surgery, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.<br /><searchLink fieldCode="AU" term="%22Ghadimi+M%22">Ghadimi M</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wienands+J%22">Wienands J</searchLink>; Institute of Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+G%22">Schneider G</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany.; Institute for Translational Cancer Research and Experimental Cancer Therapy, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Spitzner+M%22">Spitzner M</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. melanie.spitzner@med.uni-goettingen.de.<br /><searchLink fieldCode="AU" term="%22Grade+M%22">Grade M</searchLink>; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. marian.grade@med.uni-goettingen.de.; Research Training Group (RTG) 2978, University Medical Center Göttingen, Göttingen, Germany. marian.grade@med.uni-goettingen.de.; CCC-N (Comprehensive Cancer Center Lower Saxony), Göttingen, Germany. marian.grade@med.uni-goettingen.de.
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