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Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.

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Title: Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.
Authors: Milletti G; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark.; Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Università Cattolica del Sacro Cuore, 00168Rome, Italy., Cadeddu G; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168Rome, Italy., Adelantado-Rubio A; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark., Ferraina C; Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Università Cattolica del Sacro Cuore, 00168Rome, Italy., Keuper K; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark., Munk SHN; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark., De Stefanis C; Research Facilities, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy., Quacquarini D; Pathology Unit, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy., Rossi S; Pathology Unit, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy., Mastronuzzi A; Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy.; Department of Health Science and Public Health, Catholic University of the Sacred Heart, 00168Rome, Italy., Locatelli F; Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy.; Department of Health Science and Public Health, Catholic University of the Sacred Heart, 00168Rome, Italy., Grumati P; Telethon Institute of Genetics and Medicine, Pozzuoli, 80078Naples, Italy., Cianfanelli V; Department of Science, University 'ROMA TRE', 00146 Rome, Italy., Nazio F; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy., Bartek J; Genome Integrity Group, Danish Cancer Institute, 2100Copenhagen, Denmark.; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet, S-171 21 Stockholm, Sweden.; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee DD19SY, United Kingdom., Maya-Mendoza A; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark., Cecconi F; Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Università Cattolica del Sacro Cuore, 00168Rome, Italy.; Gemelli Science and Technology Park (GSTeP) - BI-Org Research Core Facility, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Jun 22; Vol. 54 (12).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.
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  Data: <searchLink fieldCode="AU" term="%22Milletti+G%22">Milletti G</searchLink>; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark.; Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Università Cattolica del Sacro Cuore, 00168Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cadeddu+G%22">Cadeddu G</searchLink>; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Adelantado-Rubio+A%22">Adelantado-Rubio A</searchLink>; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ferraina+C%22">Ferraina C</searchLink>; Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Università Cattolica del Sacro Cuore, 00168Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Keuper+K%22">Keuper K</searchLink>; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Munk+SHN%22">Munk SHN</searchLink>; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22De+Stefanis+C%22">De Stefanis C</searchLink>; Research Facilities, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Quacquarini+D%22">Quacquarini D</searchLink>; Pathology Unit, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rossi+S%22">Rossi S</searchLink>; Pathology Unit, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mastronuzzi+A%22">Mastronuzzi A</searchLink>; Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy.; Department of Health Science and Public Health, Catholic University of the Sacred Heart, 00168Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Locatelli+F%22">Locatelli F</searchLink>; Hematology/Oncology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, 00165Rome, Italy.; Department of Health Science and Public Health, Catholic University of the Sacred Heart, 00168Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Grumati+P%22">Grumati P</searchLink>; Telethon Institute of Genetics and Medicine, Pozzuoli, 80078Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cianfanelli+V%22">Cianfanelli V</searchLink>; Department of Science, University 'ROMA TRE', 00146 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nazio+F%22">Nazio F</searchLink>; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bartek+J%22">Bartek J</searchLink>; Genome Integrity Group, Danish Cancer Institute, 2100Copenhagen, Denmark.; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institutet, S-171 21 Stockholm, Sweden.; Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee DD19SY, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Maya-Mendoza+A%22">Maya-Mendoza A</searchLink>; DNA Replication and Cancer Group, Danish Cancer Institute, 2100Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Cecconi+F%22">Cecconi F</searchLink>; Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Università Cattolica del Sacro Cuore, 00168Rome, Italy.; Gemelli Science and Technology Park (GSTeP) - BI-Org Research Core Facility, Fondazione Policlinico Agostino Gemelli IRCCS, 00168 Rome, Italy.
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