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Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study.

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Title: Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study.
Authors: Pontes CDN; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil., Zampieri FG; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Department of Critical Care Medicine, University of Alberta - Alberta, Canada., Figueiredo RC; Hospital São José, Centro Universitário do Espírito Santo - Colatina (ES), Brazil., Pedro RAM; Intensive Care Unit, Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil., Malbouisson LMS; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Intensive Care Unit, Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.; Intensive Care Unit, Department of Anesthesiology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil., Cunha RCD; Hospital do Serviço Social da Indústria do Papel, Papelão e Cortiça do Estado de São Paulo - São Paulo (SP), Brazil., Ramos FJDS; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil., Damiani LP; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil., Besen BAMP; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil., Freitas FGR; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Hospital do Serviço Social da Indústria do Papel, Papelão e Cortiça do Estado de São Paulo - São Paulo (SP), Brazil., Machado FR; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.
Source: Critical care science [Crit Care Sci] 2026 Jun 22; Vol. 38, pp. e20260300. Date of Electronic Publication: 2026 Jun 22 (Print Publication: 2026).
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: Associação de Medicina Intensiva Brasileira Country of Publication: Brazil NLM ID: 9918627781706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2965-2774 (Electronic) Linking ISSN: 29652774 NLM ISO Abbreviation: Crit Care Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prospective, randomized, controlled trial assessing the effects of methylene blue for the prevention of hypotension during renal replacement therapy: protocol paper and statistical analysis plan for the BLUE study.
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  Data: <searchLink fieldCode="AU" term="%22Pontes+CDN%22">Pontes CDN</searchLink>; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Zampieri+FG%22">Zampieri FG</searchLink>; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Department of Critical Care Medicine, University of Alberta - Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Figueiredo+RC%22">Figueiredo RC</searchLink>; Hospital São José, Centro Universitário do Espírito Santo - Colatina (ES), Brazil.<br /><searchLink fieldCode="AU" term="%22Pedro+RAM%22">Pedro RAM</searchLink>; Intensive Care Unit, Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Malbouisson+LMS%22">Malbouisson LMS</searchLink>; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Intensive Care Unit, Department of Gastroenterology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.; Intensive Care Unit, Department of Anesthesiology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Cunha+RCD%22">Cunha RCD</searchLink>; Hospital do Serviço Social da Indústria do Papel, Papelão e Cortiça do Estado de São Paulo - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Ramos+FJDS%22">Ramos FJDS</searchLink>; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Damiani+LP%22">Damiani LP</searchLink>; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Besen+BAMP%22">Besen BAMP</searchLink>; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Freitas+FGR%22">Freitas FGR</searchLink>; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.; Hospital do Serviço Social da Indústria do Papel, Papelão e Cortiça do Estado de São Paulo - São Paulo (SP), Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+FR%22">Machado FR</searchLink>; Intensive Care Department, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Postgraduate Program in Translational Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo - São Paulo (SP), Brazil.; Brazilian Research in Intensive Care Network (BRICNet) - São Paulo (SP), Brazil.
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  Data: <searchLink fieldCode="JN" term="%229918627781706676%22">Critical care science</searchLink> [Crit Care Sci] 2026 Jun 22; Vol. 38, pp. e20260300. <i>Date of Electronic Publication: </i>2026 Jun 22 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Associação+de+Medicina+Intensiva+Brasileira%22">Associação de Medicina Intensiva Brasileira </searchLink><i>Country of Publication: </i>Brazil <i>NLM ID: </i>9918627781706676 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2965-2774 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2229652774%22">29652774 </searchLink><i>NLM ISO Abbreviation: </i>Crit Care Sci <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun 22
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