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SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

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Title: SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.
Authors: Mantel I; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, NY 10065, USA.; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA., Zhang H; Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY 10065, USA.; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Vargas J; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; MPH Biostatistics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Ce G; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA 02115, USA., Townsend H; Biofrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Bell R; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA., Lakhanpal A; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA., Fein MR; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA., Norman TM; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Orange DE; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Rockefeller University, New York, NY 10065, USA., Ramirez DC; Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA., DiCarlo EF; Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA., Goodman SM; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Weill Cornell Medicine, New York, NY 10065, USA., Smith MH; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Weill Cornell Medicine, New York, NY 10065, USA., Zhang F; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Division of Rheumatology, Department of Medicine, Center for Health Artificial Intelligence, University of Colorado School Anschutz Medical Campus, Aurora, CO 80045, USA., Wei K; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA 02115, USA., Dey KK; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rudensky AY; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, NY 10065, USA.; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Howard Hughes Medical Institute and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Leslie CS; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Donlin LT; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, NY 10065, USA.; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.
Corporate Authors: Accelerating Medicines Partnership: RA/SLE Network
Source: Science translational medicine [Sci Transl Med] 2026 Jun 24; Vol. 18 (855), pp. eaed3087. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: SPP1<superscript>hi</superscript> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.
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  Data: <searchLink fieldCode="AU" term="%22Mantel+I%22">Mantel I</searchLink>; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, NY 10065, USA.; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medicine, New York, NY 10065, USA.; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Vargas+J%22">Vargas J</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; MPH Biostatistics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Ce+G%22">Ce G</searchLink>; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Townsend+H%22">Townsend H</searchLink>; Biofrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA.<br /><searchLink fieldCode="AU" term="%22Bell+R%22">Bell R</searchLink>; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Lakhanpal+A%22">Lakhanpal A</searchLink>; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Fein+MR%22">Fein MR</searchLink>; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Norman+TM%22">Norman TM</searchLink>; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Orange+DE%22">Orange DE</searchLink>; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+DC%22">Ramirez DC</searchLink>; Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22DiCarlo+EF%22">DiCarlo EF</searchLink>; Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA.<br /><searchLink fieldCode="AU" term="%22Goodman+SM%22">Goodman SM</searchLink>; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Smith+MH%22">Smith MH</searchLink>; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.; Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Division of Rheumatology, Department of Medicine, Center for Health Artificial Intelligence, University of Colorado School Anschutz Medical Campus, Aurora, CO 80045, USA.<br /><searchLink fieldCode="AU" term="%22Wei+K%22">Wei K</searchLink>; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital at Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Dey+KK%22">Dey KK</searchLink>; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Rudensky+AY%22">Rudensky AY</searchLink>; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, NY 10065, USA.; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Howard Hughes Medical Institute and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational & Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Donlin+LT%22">Donlin LT</searchLink>; Immunology and Microbial Pathogenesis Graduate Program, Weill Cornell Graduate School, New York, NY 10065, USA.; HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.
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