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Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.

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Title: Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.
Authors: Gonsalves NP; Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Dellon ES; Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Kliewer KL; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Shoda T; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Yearout R; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Aceves SS; Division of Allergy, Immunology, University of California San Diego, Rady Children's Hospital, San Diego, San Diego, CA, USA., Arva NC; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Besse JA; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Caldwell JM; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Chehade M; Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Coleman A; Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Collins MH; Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and Department of Pathology & Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Anvari S; Division of Immunology, Allergy and Retrovirology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Falk GW; Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Gupta SK; Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Alabama at Birmingham, Heersink School of Medicine/Children's of Alabama, Birmingham, AL, USA., Hiremath G; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Katzka DA; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA., Khoury P; Human Eosinophil Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Leung J; Boston Specialists/Boston Food Allergy Center, Boston, MA, USA., Menard-Katcher C; Digestive Health Institute, Children's Hospital Colorado, Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, CO, USA., Menard-Katcher P; University of Colorado School of Medicine - Anschutz Medical Campus, Division of Gastroenterology and Hepatology, Aurora, CO, USA., Peterson KA; Division of Gastroenterology, University of Utah, Salt Lake City, UT, USA., Pletneva MA; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA., Spergel AKR; Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Spergel JM; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Vaysman T; Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wechsler JB; Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA., Wright BL; Division of Allergy, Asthma, and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, Phoenix Children's, Phoenix, AZ USA., Yang GY; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhang X; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Zhou M; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Bansal A; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Raphael BP; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Radwan A; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Maloney J; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Martin A; Sanofi, Morristown, NJ, USA., Deniz Y; Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA., Furuta GT; Digestive Health Institute, Children's Hospital Colorado, Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, CO, USA., Martin LJ; Division of Human Genetics, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Rothenberg ME; Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: marc.rothenberg@cchmc.org.
Corporate Authors: Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2026 Aug; Vol. 11 (8), pp. 672-688. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.
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