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Structural Basis for the Pro-amyloidogenic Action and Ligand Binding of a Novel W72R Variant of Human Apolipoprotein A-I.

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Title: Structural Basis for the Pro-amyloidogenic Action and Ligand Binding of a Novel W72R Variant of Human Apolipoprotein A-I.
Authors: Prokaeva T; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA. Electronic address: prokaeva@bu.edu., Jayaraman S; Department of Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Klimtchuk ES; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Libbey C; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Mendelson L; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Spencer B; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Chen H; Department of Pathology and Laboratory Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Van Le NH; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Sanchez A; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA; Department of Chemistry, Northwestern University, Evanston, IL, USA., Kelleher NL; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA; Department of Chemistry, Northwestern University, Evanston, IL, USA; Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Dasari S; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., McPhail ED; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Pereira L; Department of Hematology & Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Avissar U; Department of Gastroenterology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Cerda S; Department of Pathology and Laboratory Medicine, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Wong S; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Lavatelli F; Department of Molecular Medicine, University of Pavia, and Research Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Sanchorawala V; Amyloidosis Center, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA; Department of Hematology & Medical Oncology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA., Gursky O; Department of Pharmacology, Physiology & Biophysics, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA. Electronic address: gursky@bu.edu.
Source: Journal of molecular biology [J Mol Biol] 2026 Jun 24; Vol. 438 (19), pp. 169916. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
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