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SynNotch-iNOS CAR-macrophages remodel the tumor immune microenvironment and exhibit antitumor efficacy via a CD4+ T cell-dependent mechanism.

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Title: SynNotch-iNOS CAR-macrophages remodel the tumor immune microenvironment and exhibit antitumor efficacy via a CD4+ T cell-dependent mechanism.
Authors: Hong Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China., Dang B; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China., Zhou Z; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China., Liang C; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China., Li L; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China., Gao Q; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China., Zhang J; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China., Cheng SC; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China; Department of Gastroenterology, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, 361004, Fujian Province, PR China; Radboud community for infectious diseases department of internal medicine, Radboud university medical center, 6500, HB, Nijmegen, The Netherlands. Electronic address: jameschengnl@gmail.com.
Source: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2026 Sep; Vol. 295, pp. 120-132. Date of Electronic Publication: 2026 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SynNotch-iNOS CAR-macrophages remodel the tumor immune microenvironment and exhibit antitumor efficacy via a CD4<superscript>+</superscript> T cell-dependent mechanism.
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  Data: <searchLink fieldCode="AU" term="%22Hong+Y%22">Hong Y</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.<br /><searchLink fieldCode="AU" term="%22Dang+B%22">Dang B</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.<br /><searchLink fieldCode="AU" term="%22Liang+C%22">Liang C</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.<br /><searchLink fieldCode="AU" term="%22Cheng+SC%22">Cheng SC</searchLink>; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China; Department of Gastroenterology, The National Key Clinical Specialty, School of Medicine, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, 361004, Fujian Province, PR China; Radboud community for infectious diseases department of internal medicine, Radboud university medical center, 6500, HB, Nijmegen, The Netherlands. Electronic address: jameschengnl@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101280339%22">Translational research : the journal of laboratory and clinical medicine</searchLink> [Transl Res] 2026 Sep; Vol. 295, pp. 120-132. <i>Date of Electronic Publication: </i>2026 Jun 24.
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        Value: 10.1016/j.trsl.2026.06.017
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              Text: 2026 Sep
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